Recent publications

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G Caserta, C Papini, A Adamska-Venkatesh, L Pecqueur, C Sommer, E Reijerse, W Lubitz, C Gauquelin, I Meynial-Salles, D Pramanik, V Artero, M Atta, M del Barrio, B Faivre, V Fourmond, C Leger and M Fontecave, “Engineering an [FeFe]-hydrogenase: do accessory clusters influence O2resistance and catalytic bias?”, J. Am. Chem. Soc. (2018) doi: 10.1021/jacs.8b01689

M del Barrio, M Sensi, L Fradale, M Bruschi, C Greco, L de Gioia, L Bertini, V Fourmond, and C Leger, “Interaction of the H-cluster of FeFe hydrogenase with halides”, J. Am. Chem. Soc. (2018) doi:10.1021/jacs.8b01414

M. Del Barrio, Melisa and M. Sensi and C. Orain and C. Baffert and S. Dementin and V. Fourmond and C. Leger, “Electrochemical investigations of hydrogenases and other enzymes that produce and use solar fuels” Acc. Chem. Res. 51 769 (2018). doi:10.1021/acs.accounts.7b00622

M Merrouch, M Benvenuti, M Lorenzi, C Leger, V Fourmond, S Dementin, “Maturation of the [NiFe4S4] active site of carbon monoxide dehydrogenases” J. Biol. Inorg. Chem. (2018) doi:10.1007/s00775-018-1541-0

Mariam Fadel, Jean-Vincent Daurelle, Jerome Vicente, Vincent Fourmond, “Impact of alignment defects of rotating disk electrode on transport properties” Electrochimica Acta 269 534 (2018) doi:10.1016/j.electacta.2018.01.125 Free download until June 2018

C Gauquelin, C Baffert; P Richaud, E Kamionka; E Etienne, D Guieysse, L Girbal, V Fourmond, I Andre, B Guigliarelli, C Leger, P Soucaille, I Meynial-salles. “Roles of the F-domain in [FeFe] hydrogenase”, BBA Bioenergetics 1859 69-77 (2018) doi: 10.1016/j.bbabio.2017.08.010


Vincent Fourmond, “Direct Electrochemistry of Molybdenum and Tungsten Enzymes”, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier, (2017), doi:10.1016/B978-0-12-409547-2.13354-2

Lilith Domnik, Meriem Merrouch, Sebastian Goetzl, Jae-Hun Jeoung, Christophe Leger, Sebastien Dementin, Vincent Fourmond, Holger Dobbek, “CODH-IV: A novel high efficiency CO-scavenging CO dehydrogenase with increased resistance to O2” Angewandte Chemie Int. Ed. 56 15466-15469 (2017) doi:10.1002/anie.201709261

M Sensi, C Baffert, L Fradale, C Gauquelin, P Soucaille, I Meynial-Salles, H Bottin, L de Gioia, M Bruschi, V Fourmond, C Leger, L Bertini. “Photoinhibition of FeFe hydrogenase,” ACS Catalysis s 7 7378-7387 (2017). doi: 10.1021/acscatal.7b02252 [ACS Articles on request link]

M Sensi, M del Barrio, C Baffert, V Fourmond, C Leger “New perspectives in hydrogenase direct electrochemistry”, Current Opinion in Electrochemistry (2017) doi:10.1016/j.coelec.2017.08.005 Free access until Jan 19th here

Ting Zeng, Silke Leimkuhler, Ulla Wollenberger, and Vincent Fourmond, “Transient catalytic voltammetry of sulfite oxidase reveals rate limiting conformational changes” J. Am. Chem. Soc. 139 11559-11567 (2017) doi:10.1021/jacs.7b05480

V. Fourmond and C. Leger “N2 reduction: interfacing the enzyme nitrogenase with electrodes” Angewandte Chemie Int. Ed. 56, 4388-4390 (2017) doi:10.1002/anie.201701179

M. Merrouch et al, “Reliable estimation of the kinetic parameters of redox enzymes by taking into account mass transport towards rotating electrodes in protein film voltammetry experiments” Electrochimica Acta (2017) 10.1016/j.electacta.2017.03.114

V Fourmond and C. Leger, “Modelling the voltammetry of adsorbed enzymes and molecular catalysts”, Curr. Op. Electrochem 1:1, 110-120 (2017) doi:10.1016/j.coelec.2016.11.002 [preprint] Free access until May 05, 2017

Adam Kubas, Christophe Orain, David De Sancho, Laure Saujet, Matteo Sensi, Mr. Charles Gauquelin, Isabelle Meynial-Salles, Philippe Soucaille, Herve Bottin, Carole Baffert, Vincent Fourmond, Robert Best, Jochen Blumberger, Christophe Leger, “Mechanism of O2 diffusion and reduction in FeFe hydrogenase”, Nature Chemistry 9, 88-95 (2017) doi:10.1038/nchem.2592 Full text access to read only version here


V. Fourmond and C. Leger “Protein Electrochemistry: Questions and Answers” Adv Biochem Eng Biotechnol. (2016) DOI:10.1007/10_2015_5016 ERRATUM

M Sensi, C Baffert, C Greco, G Caserta, C Gauquelin, L Saujet, M Fontecave, S Roy, V Artero, P Soucaille, I Meynial-Salles, H Bottin, L de Gioia, V Fourmond, Christophe Leger and L Bertini, “Reactivity of the excited states of the H-cluster of FeFe hydrogenases,” J. Am. Chem. Soc. 138 13162-13618 (2016) doi:10.1021/jacs.6b06603

T Molle, Y Moreau, M Clemancey, F Forouhar, JL Ravanat, N Duraffourg, V Fourmond, JM Latour, S Gambarelli, EA Mulliez, and M Atta “Redox behavior of the SAM-binding Fe-S cluster in Methylthiotransferase RimO, towards under-standing dual SAM activity.” Biochemistry 55 (41), 5798-5808 (2016) doi: 10.1021/acs.biochem.6b00597

Vincent Fourmond, QSoas: a versatile software for data analysis, Anal. Chem. 88 (10), pp 5050 (2016) doi:10.1021/acs.analchem.6b00224

Pierre Ceccaldi, Emilien Etienne, Sebastien Dementin, Bruno Guigliarelli, Christophe Leger, Benedicte Burlat, “Mechanism of inhibition of NiFe hydrogenase by nitric oxide”, BBA – Bioenergetics 1857 454-61 (2016). doi: 10.1016/j.bbabio.2016.01.014


Carole Baffert , Sebastien Dementin , Vincent Fourmond , Christophe Leger, “L’electrochimie, un outil pour etudier les mecanismes enzymatiques”, L’actualite chimique, 392, 9-15, janvier 2015, [pdf] [preprint]

M. Merrouch, J Hadj-Said, L Domnik, H. Dobbek, C. Leger, S. Dementin, V. Fourmond “Inhibition of Ni-containing CO dehydrogenase by O2 is partly reversible” Chem. Eur. J 21 18934-18938 (2015) doi: 10.1002/chem.201502835

J Hadj-Saïd, ME Pandelia, C Leger, V Fourmond, S Dementin, “The Carbon Monoxide Dehydrogenase from Desulfovibrio vulgaris” BBA - Bioenergetics 1847, 1574-1583 (2015) doi:10.1016/j.bbabio.2015.08.002

P Ceccaldi, M Marques, V Fourmond, I C Pereira, C Leger “Oxidative inactivation of NiFeSe hydrogenase” Chem. Commun. 51, 14223-14226 (2015) doi:10.1039/C5CC05930E

P Ceccaldi, J Rendon, Ch Leger, R Toci, B Guigliarelli, A Magalon, S Grimaldi, V Fourmond, “Reductive Activation of E. coli Respiratory Nitrate Reductase” BBA – Bioenergetics 1847 1055-1063 (2015) doi:10.1016/j.bbabio.2015.06.007 [PDF – until August 13th]

C Orain, L Saujet, C Gauquelin, P Soucaille, I Meynial-Salles, C Baffert, V Fourmond, H Bottin, and C Leger “Electrochemical measurements of the kinetics of inhibition of two FeFe hydrogenases by O2 demonstrate that the reaction is partly reversible” J. Am. Chem. Soc. 137, 12580-12587 (2015) DOI: 10.1021/jacs.5b06934 [ACS Articles on Request]

V Fourmond, S Stapf, H Li, D Buesen, J Birrell, O Rudiger, W Lubitz, W Schuhmann, N Plumere, C Leger, “The mechanism of protection of catalysts supported in redox hydrogel films” J. Am. Chem. Soc. 137 5494-5505 (2015) doi:10.1021/jacs.5b01194 [ACS Articles on Request]

A Abou-Hamdan, P Ceccaldi, H Lebrette, O Gutierrez-Sanz, P Richaud, L Cournac, B Guigliarelli, A L. de Lacey, C Leger, A Volbeda, B Burlat and S Dementin “A Threonine Stabilizes the NiC and NiR Catalytic Intermediates of [NiFe]-hydrogenase” J. Biol. Chem. 290 8550-8558 (2015) doi:10.1074/jbc.M114.630491

Eunsun Kim, Abdellah Felouat, Elena Zaborova, Jean-Charles Ribierre, Jeong Weon Wu, Sebastien Senatore, Cedric Matthews, Pierre-François Lenne, Carole Baffert, Artak Karapetyan, Michel Giorgi, Denis Jacquemin, Miguel Ponce-Vargas, Boris Le Guennic, Frederic Fages and Anthony D’Aleo, Org. Biomol. Chem., (2015) doi:10.1039/C5OB02295A


Sigfridsson KG, Leidel N, Sanganas O, Chernev P, Lenz O, Yoon KS, Nishihara H, Parkin A, Armstrong FA, Dementin S, Rousset M, De Lacey AL, Haumann M. “Structural differences of oxidized iron-sulfur and nickel-iron cofactors in O2-tolerant and O2-sensitive hydrogenases studied by X-ray absorption spectroscopy.” Biochim Biophys Acta. 1847, 162-170, 2014 doi:10.1016/j.bbabio.2014.06.011.

Volbeda A, Martin L, Barbier E, Gutierrez-Sanz O, De Lacey AL, Liebgott PP, Dementin S, Rousset M, Fontecilla-Camps JC, “Crystallographic studies of [NiFe]-hydrogenase mutants: towards consensus structures for the elusive unready oxidized states” J Biol Inorg Chem. 20, 11-22, 2014 doi:10.1007/s00775-014-1203-9

C Greco, V Fourmond, C Baffert, P-H Wang, S Dementin, P Bertrand, M Bruschi, J Blumberger, L de Gioia, C Leger, “Combining experimental and theoretical methods to learn about the reactivity of gas-processing metalloenzymes”, Energy Environ. Sci., 7, 3543-3573 (2014). doi:10.1039/C4EE01848F (open access)

J Jacques, B Burlat, P Arnoux, M Sabaty, B Guigliarelli, C Leger, D Pignol, V Fourmond, “Kinetics of substrate inhibition of periplasmic nitrate reductase” BBA Bionergetics, 1837, 1801-1809 (2014) doi:10.1016/j.bbabio.2014.05.357

Vincent Fourmond, Claudio Greco, Kateryna Sybirna, Carole Baffert, Po-Hung Wang, Pierre Ezanno, Marco Montefiori, Maurizio Bruschi, Isabelle Meynial-Salles, Philippe Soucaille, Jochen Blumberger, Herve Bottin, Luca De Gioia and Christophe Leger, “The oxidative inactivation of FeFe hydrogenase reveals the flexibility of the H-cluster” Nature Chemistry, 6, 336-342 (2014) doi:10.1038/nchem.1892

V Hajj, C Baffert, K Sybirna, I Meynial-Salles, P Soucaille, H Bottin, V Fourmond, C Leger, “Reductive inactivation of FeFe hydrogenase and implication for catalysis” Energy and Environmental Science 7(2) 715-719 (2014) doi:10.1039/C3EE42075B

J. Jacques Julien, V. Fourmond, P. Arnoux, M. Sabaty, E. Etienne, F. Biaso, P. Bertrand, D. Pignol, C. Leger, B. Guigliarelli, B. Burlat, “Reductive activation in periplasmic nitrate reductase involves chemical modifications of the Mo-cofactor beyond the first coordination sphere of the metal ion” BBA Bionergetics 1837 277-286 (2014) doi:10.1016/j.bbabio.2013.10.013


Contribution to Practical Approaches to Biological Inorganic Chemistry

Structure et fonction des hydrogenases, C. Leger et S. Dementin, chapitre du livre L’energie à decouvert (2013)

P. Bertrand, “Molecular Modelling of Proton Transfer Kinetics in Biological System” in “Reaction rate constant computations, theories and applications”, RSC Theoretical and Computational Chemistry Series, (2013). ISBN:978-1-84973-650-3 doi:10.1039/9781849737753-00379 [pdf]

V. Fourmond, C Baffert, K Sybirna, S Dementin, A Abou-Hamdan, I Meynial-Salles, Ph Soucaille, H Bottin, C Leger “The mechanism of inhibition by H2 of H2-evolution by hydrogenases” Chem. Commun 49, 6840-6842 (2013) doi:10.1039/C3CC43297A This is a Hot Chem Comm paper for June 2013

V. Fourmond, C. Baffert, K. Sybirna, T. Lautier, A. Abou Hamdan, S. Dementin, P. Soucaille, I. Meynial-Salles, H. Bottin and C. Leger, “Steady-state catalytic wave-shapes for 2-electron reversible electrocatalysts and enzymes” J. Am. Chem. Soc. 125 3926 (2013). doi:10.1021/ja311607s

A Abou Hamdan , B Burlat , O Gutierrez-Sanz , PP Liebgott , C Baffert , A de Lacey , M Rousset , B Guigliarelli , C Leger and S. Dementin, “O2-independent formation of the inactive states of NiFe hydrogenase” Nat. Chem. Biol. 9 15-17 (2013) doi:10.1038/NCHEMBIO.1110 M. J. Maroney (News and views) Nat. Chem. Biol (2013) doi:10.1038/nchembio.1139

T. Miyake, M. Bruschi, U. Cosentino, C. Baffert, V. Fourmond, C Leger, G. Moro, L. De Gioia, C. Greco. “Does the environment around the H-cluster allow coordination of the pendant amine to the catalytic iron center in [FeFe] hydrogenases? Answers from theory” J Biol Inorg Chem 18 693-700 (2013) doi:10.1007/s00775-013-1014-4

Kateryna Sybirna, P Ezanno, C Baffert, C Leger, H Bottin, “Arginine171 of Chlamydomonas reinhardtii FeFe hydrogenase HydA1 plays a crucial role in electron transfer to its catalytic center” Int. J. Hydrogen Energy 7 2998 2013 doi:10.1016/j.ijhydene.2012.12.078

S. Canaguier, V. Fourmond, C.U. Perotto, J. Fize, J. Pecaut, M. Fontecave, M.J. Field and V. Artero “Catalytic hydrogen production by a NiRu mimic of NiFe hydrogenases involves a proton-coupled electron transfer step” Chem. Commun. 49 5004-5006 (2013) doi:10.1039/C3CC40987B

S Chambon, A D’Aleo, C Baffert, G Wantz and F Fages “Solution-processed bulk heterojunction solar cells based on BF2- hydroxychalcone complexes” Chem. Commun. 49 3555 (2013) doi:10.1039/C3CC41351A

A Jacques, M Clemancey, G Blondin, V Fourmond, JM Latour, and O Seneque “Cyclic Peptide-Based Redox-Active Model of Rubredoxin” Chem. Commun. 49 2915 (2013) doi:10.1039/C3CC40517F


R van Lis, C Baffert, Y Coute, W. Nitschke, A. Atteia “Chlamydomonas reinhardtii chloroplasts contain a homodimeric pyruvate:ferredoxin oxidoreductase that functions with FDX1” Plant Physiology pp.112.208181 (2012) doi:10.1104/pp/112.208181

A Abou Hamdan , PP Liebgott , V Fourmond , O Gutierrez-Sanz , A L De Lacey , P Infossi , M Rousset , S Dementin , C Leger, “Relation between anaerobic inactivation and oxygen tolerance in a large series of NiFe hydrogenase mutants” Proc. natl. Acad. Sc. USA 109 19916-19921 (2012) doi:10.1073/pnas.1212258109

C. Baffert, K. Sybirna, P. Ezanno, T. Lautier, V. Hajj, I. Meynial-Salles, P. Soucaille, H. Bottin and C. Leger, “Covalent attachment of FeFe hydrogenases to carbon electrodes for direct electron transfer”, Anal. Chem. 84 7999 (2012) doi:10.1021/ac301812s

A. Abou Hamdan, S. Dementin, P.-P. Liebgott, O. Gutierrez-Sanz, P. Richaud, A. L. De Lacey, M. Rousset, P. Bertrand, L. Cournac and C. Leger, “Understanding and tuning the catalytic bias of hydrogenase” J. Am. Chem. Soc. 134 8368-8371 (2012) doi:10.1021/ja301802r


S. Dementin, C. Burlat, V. Fourmond, F. Leroux, P.P. Liebgott, A. Abou Hamdan, C. Leger, M. Rousset, B. Guigliarelli, P. Bertrand, “Rates of intra and intermolecular electron transfers in hydrogenase deduced from steady-state activity measurements” J. Am. Chem. Soc. 133 10211 (2011) doi: 10.1021/ja202615a

C Baffert, L Bertini, T Lautier, C Greco, K Sybirna, P Ezanno, E Etienne, P Soucaille, P Bertrand, H Bottin, I Meynial-Salles, L De Gioia, C Leger “CO disrupts the reduced H-cluster of FeFe hydrogenase. A combined DFT and PFV study” J. Am. Chem. Soc. 133 2096-2099 (2011) doi: 10.1021/ja110627b

P-P Liebgott, A L. de Lacey, B Burlat, L Cournac, P Richaud, M Brugna, V M. Fernandez, B Guigliarellia, M Rousset, C Leger, S Dementin “Original design of an oxygen-tolerant [NiFe] hydrogenase : Major effect of a valine-to-cysteine mutation near the active site” J. Am. Chem. Soc. 133 986-997 (2011) doi:10.1021/ja108787s

O. Kolaj-Robin, S. R O’Kane, W. Nitschke, C. Leger, F. Baymann, T. Soulimane. “Biochemical and biophysical characterization of succinate:quinone reductase from Thermus thermophilus” BBA – Bioenergetics, 1807 68-79 (2011) doi:10.1016/j.bbabio.2010.10.009

T. Lautier, P. Ezanno, C. Baffert, V. Fourmond, L. Cournac, Juan C. Fontecilla-Camps, P. Soucaille, P. Bertrand, I. Meynial-Salles, Christophe Leger. “The quest for a functional substrate access tunnel in FeFe hydrogenase” Faraday Discussions, 148, 385-407 (2011). doi:10.1039/c004099c

P.P. liebgott, S. Dementin, C. Leger and M. Rousset “Towards engineering O2-tolerance in NiFe hydrogenases” Energy and Environmental Science, 4, 33-41 (2011) doi:10.1039/c0ee00093k


M.E. Pandelia, V. Fourmond, P. Tron, E. Lojou, P. Bertrand, C. Leger, M.T. Giudici-Orticoni, W. Lubitz “The Membrane-Bound Hydrogenase I from the Hyperthermophilic Bacterium Aquifex aeolicus: Enzyme Activation, Redox Intermediates and Oxygen Tolerance” J. Am. Chem. Soc. 132(20) 6991-7004 (2010) doi:10.1021/ja910838d

V. Fourmond, P. Infossi, MT Giudici-Orticoni, P. Bertrand, C. Leger “Two-step chronoamperometric method for studying the anaerobic inactivation of an oxygen tolerant NiFe hydrogenase” J. Am. Chem. Soc. 132(13), 4848-4857 (2010) doi:10.1021/ja910685j [pdf]

F. Leroux, PP Liebgott, L. Cournac, P. Richaud, A. Kpebe, B. Burlat, B. Guigliarelli, P. Bertrand, C. Leger, M. Rousset, S. Dementin “Is engineering O2-tolerant hydrogenases just a matter of reproducing the active sites of the naturally occurring O2-resistant enzymes?” Int. J. H2 Energ. 35, 10770-10777 (2010) doi:10.1016/j.ijhydene.2010.02.071

C. Valls, J.F. Colom, C. Baffert, I. Gimbert, M. B. Roncero, J.-C. Sigoillot “Comparing the efficiency of the laccaseNHA and laccaseHBT systems in eucalyptus pulp bleaching” Biochem. Engin. J. 49(3) 401-407 (2010) doi:10.1016/j.bej.2010.02.002

V. Fourmond, B. Burlat, S. Dementin, M. Sabaty, P. Arnoux, E. Etienne, B. Guigliarelli, P. Bertrand, D. Pignol and C. Leger. “Dependence of catalytic activity on driving force in solution assays and protein film voltammetry: insights from the comparison of nitrate reductase mutants” Biochemistry 49(11) 2424-2432 (2010) doi:10.1021/bi902140e [pdf]

V. Fourmond, M. Sabaty, P. Arnoux, P. Bertrand, D. Pignol and C. Leger. “Reassessing the Strategies for Trapping Catalytic Intermediates during Nitrate Reductase Turnover” J. Phys. Chem. B 114(9) 3341-3347 (2010) doi:10.1021/jp911443y [pdf]

P.-P. Liebgott, F. Leroux, B. Burlat, S. Dementin, C. Baffert, Th. Lautier, V. Fourmond, P. Ceccaldi, Ch. Cavazza, I. Meynial-Salles, Ph. Soucaille, J. Fontecilla-Camps, B. Guigliarelli, P. Bertrand, M. Rousset, Ch. Leger. “Relating diffusion along the substrate tunnel and oxygen sensitivity in hydrogenase” Nat. Chem. Biol. 6(1) 63-70 (2010) doi:10.1038/nchembio.276


S. Romain, C. Baffert, C. Duboc, J.-C. Lepretre, A. Deronzier, M.-N. Collomb, “Mononuclear MnIII and MnIV Bis-terpyridine Complexes: Electrochemical Formation and Spectroscopic Characterizations” Inorg. Chem. 48 3125 (2009) doi:10.1021/ic8024342"

K. H. Diêp Lê, A. Boussac, B. Frangioni, Ch. Leger, F. Lederer “Interdomain Contacts in Flavocytochrome b2, a Mutational Analysis” Biochemistry, 48, 10803-10809 (2009) doi:10.1021/bi901301r [pdf]

S. Dementin, F. Leroux, L. Cournac, A. De Lacey, A. Volbeda, C. Leger, B. Burlat, N. Martinez, S. Champ, L. Martin, O. Sanganas, M. Haumann, V. Fernandez, B. Guigliarelli, J. Fontecilla-Camps, M. Rousset. “Introduction of Methionines in the Gas Channel Makes [NiFe] Hydrogenase Aero-Tolerant” J. Am. Chem. Soc., 131, 10156-10164 (2009) doi:10.1021/ja9018258 [pdf]

V. Fourmond, T. Lautier, C. Baffert, F. Leroux, P.-P. Liebgott, S. Dementin, M. Rousset, P. Arnoux, D. Pignol, I. Meynial, P. Soucaille, P. Bertrand, C. Leger. “Correcting for electrocatalyst desorption and inactivation in chronoamperometry experiments.” Analytical Chemistry, 81, 1962-2968 (2009) doi:10.1021/ac8025702 [pdf]

V. Fourmond, K. Hoke, H. A. Heering, C. Baffert, F. Leroux, P. Bertrand, C. Leger “SOAS: a free software to analyse electrochemical data and other one-dimensional signals” Bioelectrochemistry, 76, 141-147 (2009) doi:10.1016/j.bioelechem.2009.02.010 [pdf]


V. Fourmond, B. Burlat, S. Dementin, P. Arnoux, M. Sabaty, S. Boiry, B. Guigliarelli, P. Bertrand, D. Pignol and C. Leger “Major Mo(V) EPR signature of Rhodobacter sphaeroides periplasmic nitrate reductase arising from a dead-end species that activates upon reduction. Relation to other molybdoenzymes from the DMSO reductase family.” J. Phys. Chem. B 112, 15478-15486 (2008) doi:10.1021/jp807092y [pdf] [Supplement]

F. Leroux, S. Dementin, B. Burlat, L. Cournac, A. Volbeda, S. Champ, L. Martin, B. Guigliarelli, P. Bertrand, J. Fontecilla-Camps, M. Rousset and C. Leger “Experimental Approaches to Kinetics of Gas Diffusion in Hydrogenase” Proc. Natl. Acad. Sci. USA 105, 11188 (2008) doi:10.1073/pnas.0803689105 [pdf] [Supplement]

C. Leger and P. Bertrand. “Direct electrochemistry of redox enzymes as a tool for mechanistic studies” Chem. Rev. 108, 2379 (2008) doi:10.1021/cr0680742 [html] [pdf] [Supplement] This is part of the July, special issue on Molecular and biomolecular electrochemistry

C. Baffert, M. Demuez, L. Cournac, B. Burlat, B. Guigliarelli, P. Bertrand, L. Girbal and C. Leger. “Hydrogen-activating enzymes: activity does not correlate with oxygen sensitivity” Angewandte Chemie Int. Ed. 47, 2052 (2008) doi:10.1002/anie.200704313 [Supplement]


P. Lanciano, A. Savoyant, S. Grimaldi, A. Magalon, B. Guigliarelli and P. Bertrand. “New Method for the Spin Quantitation of [4Fe-4S]+ Clusters with S=3/2. Application to the FS0 Center of the NarGHI Nitrate Reductase from Escherichia coliJ. Phys. Chem. B 111, 13632 (2007). doi:10.1021/jp075243t [pdf]

P. Bertrand, B. Frangioni, S. Dementin, M. Sabaty, P. Arnoux, B. Guigliarelli, D. Pignol and C. Leger. "Effects of slow substrate binding and release in redox enzymes: theory and application to periplasmic nitrate reductase.’’ J. Phys. Chem. B 111, 10300 (2007). doi:10.1021/jp074340j [pdf]

P. Lanciano, A. Magalon, P. Bertrand, B. Guigliarelli, S. Grimaldi “High-stability semiquinone intermediate in nitrate reductase A (NarGHI) from Escherichia coli is located in a quinol oxidation site close to heme bD” Biochemistry 17, 869 (2007). doi:10.1021/bi700074y

S. Dementin, P. Arnoux, B. Frangioni, S. Grosse, C. Leger, B. Burlat, B. Guigliarelli, M. Sabaty, D. Pignol. “Access to the Active Site of Periplasmic Nitrate Reductase: Insights from Site-Directed Mutagenesis and Zinc Inhibition Studies” Biochemistry 38, 12240 (2007) doi:10.1021/bi700928m [pdf]

M. G. Almeida, Celia M. Silveira, B. Guigliarelli, P. Bertrand, J. J. G. Moura, I. Moura and C. Leger. “A needle in a haystack: the active site of the membrane-bound complex cytochrome c nitrite reductase.” FEBS Letters 581, 284 (2007). doi:10.1016/j.febslet.2006.12.023


S. Dementin, V. Belle, P. Bertrand, B. Guigliarelli, G. Adryanczyk-Perrier, A. Delacey, V. M. Fernandez, M. Rousset and C. Leger. “Changing the ligation of the distal [4Fe4S] cluster in NiFe hydrogenase impairs inter- and intramolecular electron transfers” J. Am. Chem. Soc. 128, 5209 (2006) doi:10.1021/ja060233b [pdf]

C. Leger, F. Lederer, B. Guigliarelli and P. Pertrand, “Electron flow in multicenter enzymes: theory, applications and consequences on the natural design of redox chains” J. Am. Chem. Soc. 128, 180 (2006) doi:10.1021/ja055275z [pdf]

M. Guiral, P. Tron, V. Belle, C. Aubert, C. Leger, B. Guigliarelli and M.-T. Giudici-Orticoni. “Hyperthermostable and oxygen resistant hydrogenases from a hyperthermophilic bacterium Aquifex aeolicus: Physicochemical properties” Int. J. Hydrogen. Energ. 31, 1414 (2006) doi:10.1016/j.ijhydene.2006.06.007


C. More, M. Asso, G. Roger, B. Guigliarelli, J. Caldeira, J. Moura and P. Bertrand, “Study of the Spin-Spin Interactions between the Metal Centers of Desulfovibrio gigas Aldehyde Oxidoreductase: Identification of the Reducible Sites of the [2Fe-2S]1+,2+ Clusters” Biochemistry 44, 11628 (2005) doi:10.1021/bi0510025


C. Leger, S. Dementin, P. Bertrand, M. Rousset and B. Guigliarelli, “Inhibition and aerobic inactivation kinetics of Desulfovibrio fructosovorans NiFe hydrogenase studied by Protein Film voltammetry” J. Am. Chem. Soc. 126, 12162 (2004) doi:10.1021/ja046548d [pdf]

B. Frangioni, P. Arnoux, M. Sabaty, D. Pignol, P. Bertrand, B. Guigliarelli and C. Leger “In Rhodobacter sphaeroides respiratory nitrate reductase, the kinetics of substrate binding favors intramolecular electron transfer” J. Am. Chem. Soc., 126, 1328 (2004) doi:10.1021/ja0384072 [pdf]

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