Henrik Kacser (1918-1995): Published work

This page contains a list of the publications of Henrik Kacser. An annotated version may be found on another page.

1. KACSER, H. & UBBELOHDE, A. R. (1949). A thermostatically controlled micro-polarimeter tube. J. Soc. Chem. Ind. 68, 135-138
2. KACSER, H. & UBBELOHDE, A. R. (1949). Thermodynamic conditions for the retention of solvents by crystals: the system brucine/benzene. Nature 164, 445-446.
3. KACSER, H. & UBBELOHDE, A. R. (1950). Thermodynamic factors in stereospecific processes. J. Chem. Soc. 2152-2158.
4. KACSER, H. (1950). The purification of brucine. J. Chem. Soc. 2908.
5. KACSER, H. (1952). The specificity and kinetics of aconitase. Biochim. Biophys. Acta 9, 406-415.
6. KACSER, H. (1952). The probability factor in bimolecular reactions. I. Uncomplicated ion-dipole systems. J. Phys. Chem. 56, 1101-1106.
7. KACSER, H. (1955). The cortical changes on fertilization of the sea-urchin egg. J. Exp. Biol. 32, 451-467.
8. KACSER, H. (1956) Molecular organization of genetic material. Science 124, 151-154.
9. BEALE, G. H. & KACSER, H. (1957) Studies on the antigens of Paramecium aurelia with the aid of fluorescent antibodies. J. Gen. Microbiol. 17, 68-74.
10. KACSER, H. (1957) The heat inactivation and serum neutralization sites of bacteriophage T2. Proc. Roy. Phys. Soc. Edinburgh 26, 1-6.
11. KACSER, H. (1957). Some physico-chemical aspects of biological organisation. Appendix to The strategy of the genes by C. H. Waddington, pp. 191-249. George Allen and Unwin, London
12. KACSER, H. (1960). Kinetic models of development and heredity. Symp. Soc. Exp. Biol. 14, 13-27.
13. KACSER, H. (1963). The kinetic structure of organisms, in Biological organization at the cellular and supercellular level (Harris, R. J. C., ed.), pp. 25-41, Academic Press, New York and London
14. BURNS, J. A., CURTIS, C. F. & KACSER, H. (1965). A method for the production of a desired buffer gradient and its use for the chromatographic separation of argininosuccinate. J. Chromatog. 20, 310-318.
15. KACSER, H. & BURNS, J. A. (1967). Causality, complexity and computers, in Quantitative biology of metabolism (Locker, A., ed.), pp. 11-23, Springer Verlag, Berlin
16. KACSER, H., BULFIELD, G. & WALLACE, M. E. (1973). Histidinaemic mutant in the mouse. Nature 244, 77-79.
17. KACSER, H. & BURNS, J. A. (1973). The control of flux. Symp. Soc. Exp. Biol. 27, 65-104.
18. BULFIELD, G. & KACSER, H. (1974) Histidinaemia in man and mouse. Arch. Dis. Childh. 49, 545-552.
19. BARTHELMESS, I. B., CURTIS, C. F. & KACSER, H. (1974). Control of the flux to arginine in Neurospora crassa: de-repression of the last three enzymes of the arginine pathway. J. Mol. Biol. 87, 303-316
20. BULFIELD, G. & KACSER, H. (1975). Histamine and histidine levels in the brain of the histidinaemic mutant mouse. J. Neurochem. 24, 403-405.
21. KACSER, H. (1976) The proper solutions of Kacser's developmental model. J. theor. Biol. 63, 239-241.
22. BURNS, J. A. & KACSER, H. (1977) Allosteric repression: an analysis. J. theor. Biol. 68, 199-213.
23. KACSER, H., MYA, K. M., DUNKER, M., WRIGHT, A. F., BULFIELD, G., McLAREN, A. & LYON, M. F. (1977) Maternal histidine metabolism and its effect on foetal development in the mouse. Nature 265, 262-266.
24. BULFIELD, G., MOORE, E. A. & KACSER, H. (1978). Genetic variation in activity of the enzymes of glycolysis and gluconeogenesis between inbred strains of mice. Genetics 89, 551-561.
25. KACSER, H., BULFIELD, G. & WRIGHT, A. F. (1979). The biochemistry and genetics of histidinaemia in the mouse, in Models for the study of inborn errors of metabolism (Hommes, F. A., ed.), pp. 33-43, Elsevier, Amsterdam.
26. KACSER, H., MYA, K. M. & BULFIELD, G. (1979). Endogenous teratogenesis in maternal histidinaemia, in Models for the study of inborn errors of metabolism (Hommes, F. A., ed.), pp. 43-53, Elsevier, Amsterdam.
27. KACSER, H. & BURNS, J. A. (1979). Molecular democracy: who shares the controls? Biochem. Soc. Trans. 7, 1149-1161.
28. FLINT, H. J., PORTEOUS, D. J. & KACSER, H. (1980). Control of flux in the arginine pathway of Neurospora crassa. The flux from citrulline to arginine. Biochem. J. 190, 1-15.
29. KACSER, H. & BURNS, J. A. (1981). The molecular basis of dominance. Genetics 97, 639-666.
30. WRIGHT, A. F., BULFIELD, G., ARFIN, S. H. & KACSER, H. (1982). Comparison of the properties of histidine ammonia-lyase in normal and histidinaemic mutant mice. Biochem. Genet. 20, 245-263.
31. FLINT, H. J., TATESON, R. W., BARTHELMESS, I. B., PORTEOUS, D. J., DONACHIE, W. D. & KACSER, H. (1981). Control of flux in the arginine pathway of Neurospora crassa. Modulations of enzyme activity and concentration. Biochem. J. 200, 231-246.
32. KACSER, H. (1983). The control of enzyme systems in vivo. Elasticity analysis of the steady state. Biochem. Soc. Trans. 11, 35-40.
33. MIDDLETON, R. J. & KACSER, H. (1983). Enzyme variation, metabolic flux and fitness: alcohol dehydrogenase in D. melanogaster. Genetics 105, 633-650.
34. KACSER, H. & BEEBY, R. (1984). Evolution of catalytic proteins: on the origin of enzyme species by means of natural selection. J. Mol. Evol. 20, 38-51.
35. FLINT, H. J., DIBLE, S. & KACSER, H. (1985). Derepression of enzyme synthesis is response to arginine limitation in Neurospora crassa. J. Gen. Microbiol 131, 2891-2900.
36. TORRES, N. V., MATEO, F., MELÉNDEZ-HEVIA, E. & KACSER, H. (1986) Kinetics of metabolic pathways. A system in vitro to study the general control of flux. Biochem. J. 234, 169-174.
37. STUART, F., PORTEOUS, D. J., FLINT, H. J. & KACSER, H. (1986). Control of the arginine flux in the arginine pathway of Neurospora crassa: effects of co-ordinate changes of enzyme concentration. J. Gen. Microbiol 132, 1159-1166.
38. HOFMEYR, J.-H. S., KACSER, H. & VAN DER MERWE, K. (1986). Metabolic control analysis of moiety-conserved cycles. Eur. J. Biochem. 155, 631-641.
39. KACSER, H. & PORTEOUS, J. W. (1987). Control of metabolism: what do we have to measure? Trends Biochem. Sci. 12, 5-14.
40. KACSER, H. (1987) Regulation and control of metabolic pathways, in Physiological models (Basin, M. J. & Prosser, J. I., eds.), pp. 1-23, CRC Press, Boca Raton.
41. KACSER, H. (1987) Control of metabolism, in The biochemistry of plants (Davies, D. D., ed.), vol. 11, 39-66.
42. KEIGHTLEY, P. D. & KACSER, H. (1987). Dominance, pleiotropy and metabolic structure. Genetics 117, 319-329.
43. BURNS, J. E. & KACSER, H. (1987). Genetic effects on susceptibility to histidine-induced teratogenesis in the mouse. Genet. Res. Camb. 50, 147-153.
44. KACSER, H. (1987). On parts and wholes in metabolism, in The organization of cell metabolism (Welch, G. R. & Clegg, J. S., eds.), pp. 327-337, Plenum, New York.
45. KACSER, H. (1987) Dominance not inevitable but very likely. J. theor. Biol. 125, 505-506.
46. ACERENZA, L., SAURO, H. M. & KACSER, H. (1989). Control analysis of time-dependent metabolic systems. J. theor. Biol. 137, 423-444.
47. KACSER, H. (1989) Quantitative variation and the control analysis of enzyme systems, in Evolution and animal breeding (Hill, W. G. & Mackay, T. F. C., eds.), pp. 219-226, CAB International, Wallingford, Oxfordshire, UK
48. KACSER, H., SAURO, H. M. & ACERENZA, L. (1990) Enzyme-enzyme interactions and control analysis. 1. The case of non-additivity: monomer-oligomer associations. Eur. J. Biochem. 187, 481-491.
49. SAURO, H. M. & KACSER, H. (1990) Enzyme-enzyme interactions and control analysis. 2. The case of non-independence: heterologous associations. Eur. J. Biochem. 187, 493-500.
50. MELÉNDEZ-HEVIA, E., TORRES, N. V., SICILIA, J. & KACSER, H. (1990) Control analysis of transition times in metabolic systems. Biochem. J. 265, 195-202.
51. KACSER, H., SAURO, H. M. & ACERENZA, L. (1990) Control analysis of systems with enzyme-enzyme interactions, in Control of metabolic processes (Cornish-Bowden, A. & Cárdenas, M. L., eds.), pp. 251-257, Plenum, New York
52. ACERENZA, L. & KACSER, H. (1990) Enzyme kinetics and metabolic control. A method to test and quantify the effect of enzymic properties on metabolic variables. Biochem. J. 269, 697-707.
53. BEEBY, R. & KACSER, H. (1990) Metabolic constraints in evolution, in Organizational constraints on the dynamics of evolution (Maynard Smith, J. & Vida, G., eds.), pp. 1-22, Manchester University Press, Manchester.
54. KACSER, H. (1991) A superior theory? J. theor. Biol. 149, 141-144.
55. NIEDERBERGER, P., PRASAD, R., MIOZZARI, G. & KACSER, H. (1992). A strategy for increasing an in vivo flux by genetic manipulation. The tryptophan system of yeast. Biochem. J. 287, 473-479.
56. KACSER, H. & ACERENZA, L. (1993). A universal method for achieving increases in metabolite production. Eur. J. Biochem. 216, 361-367.
57. SMALL, J. R. & KACSER, H. (1993). Responses of metabolic system to large changes in enzyme activities and effectors. 1. The linear treatment of unbranched chains. Eur. J. Biochem. 213, 613-624.
58. SMALL, J. R. & KACSER, H. (1993). Responses of metabolic system to large changes in enzyme activities and effectors. 2. The linear treatment of branched pathways and metabolite concentrations. Assessment of the general non-linear case. Eur. J. Biochem. 213, 625-640.
59. SMALL, J. R. & KACSER, H. (1994). A method for increasing the concentration of a specific internal metabolite in steady-state systems. Eur. J. Biochem. 226, 649-656.
60. KACSER, H., BURNS, J. A. & FELL, D. A. (1995). The control of flux. Biochem. Soc. Trans. 23, 341-366 (updated reprint of the 1973 article).
61. KACSER, H. (1995). Recent developments beyond metabolic control analysis. Biochem. Soc. Trans. 23, 387-391.
62. CASCANTE, M., E. MELÉNDEZ-HEVIA, B. KHOLODENKO, J. SICILIA & H. KACSER (1995). Control analysis of transit time for free and enzyme-bound metabolites: physiological and evolutionary significance of metabolic response times. Biochem. J. 308, 895-899.
63. KACSER, H. & SMALL, J. R. (1996). How many phenotypes from one genotype? The case of prion diseases. J. theor. Biol. 182, 209-218.