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In memory of Henrik Kacser:
Special issue of the Journal of Theoretical Biology

This page describes the special issue of the Journal of Theoretical Biology 182, pp. 193-457 (1996) that was published in memory of Henrik Kacser (1918-1995) and was organized by Athel Cornish-Bowden. This page and those associated with it will continue to be available as long as there are a significant number of accesses to them, but they will eventually be deleted from the server.

Henrik Kacser

David A. Fell (Oxford): Dr Henrik Kacser (1918-1995): 193-194.

Athel Cornish-Bowden (Marseilles): Henrik Kacser (1918-1995): an annotated bibliography: 195-199.

Luis Acerenza, María Luz Cárdenas, Marta Cascante, Jannie Hofmeyr, Enrique Meléndez-Hevia, Judit Ovádi, Patti A. Quant, Rankin Small, Stefan Szedlacsek: Personal glimpses of Henrik Kacser: 201-207.

Henrik Kacser and J. Rankin Small (Edinburgh): How many phenotypes from one genotype? The case of prion diseases: 209-218. [Abstract]

Arthur R. Peacocke (Oxford): A pioneer of the kinetic approach: 219-222. [Summary]

John W. Porteous (Aberdeen): Dominance – one hundred and fifteen years after Mendel’s paper: 223-232. [Abstract]

Theory: general aspects

Vassily Hatzimanikatis and James E. Bailey (Zürich): MCA has more to say: 232-242. [Abstract]

Reinhart Heinrich and Edda Klipp (Berlin): Control analysis of unbranched enzymatic chains in states of maximal activity: 243-252. [Abstract]

Jean-Pierre Mazat, Christine Reder and Thierry Letellier (Bordeaux): Why are most flux control coefficients so low? 253-258

Stefan Schuster (Berlin): Control analysis in terms of generalized variables characterizing metabolic systems: 259-268. [Abstract]

Asok K. Sen (Indianapolis): On the sign pattern of metabolic control coefficients: 269-275. [Abstract]

Theory: control design

Luis Acerenza (Montevideo): How constrained is metabolic control? 277-283. [Abstract]

Simon Thomas and David A. Fell (Oxford): Design of metabolic control for large flux changes: 285-298. [Abstract]

Theory: genetic aspects

Ueli Grossniklaus, M. S. Madhusudhan and Vidyanand Nanjundiah (Bangalore): Non-linear enzyme kinetics can lead to high metabolic flux control coefficients: implications for the evolution of dominance: 299-302. [Abstract]

Daniel L. Hartl and Clifford H. Taubes (Harvard): Compensatory nearly neutral mutations: selection without adaptation: 303-309. [Abstract]

Peter D. Keightley (Edinburgh): Metabolic models of selection response: 311-316. [Abstract]

Theory: temporal aspects

Marta Cascante (Barcelona), Mónica Lloréns (Madrid), Enrique Meléndez-Hevia (La Laguna), Joaquim Puigjaner (Barcelona), Francisco Montero (Madrid) and Enric Martí (Barcelona): The metabolic productivity of the cell factory: 317-325. [Abstract]

John S. Easterby (Liverpool): The fusion of control analysis and temporal analysis of metabolic systems: 327-331. [Abstract]

Enrique Meléndez-Hevia, Joaquín Sicilia, María Teresa Ramos (La Laguna), Enric I. Canela and Marta Cascante (Barcelona): Molecular bureaucracy: who controls the delays? 333-339. [Abstract]

Stefan E. Szedlacsek, Alexandru R. Aricescu (Bucharest) and Bent H. Havsteen (Kiel): Time-dependent control of metabolic systems by external effectors: 341-350. [Abstract]

Theory: experimental approaches

Martin D. Brand (Cambridge): Top down metabolic control analysis: 351-360. [Abstract]

Christoph Giersch (Darmstadt) and Athel Cornish-Bowden (Marseilles): Extending double modulation: combinatorial rules for identifying the modulations necessary for determining elasticities in metabolic pathways: 361-369. [Abstract]

Jan-Hendrik S. Hofmeyr (Stellenbosch) and Athel Cornish-Bowden (Marseilles): Co-response analysis: a new strategy for experimental metabolic control analysis: 371-380. [Abstract]

Stefan Krauss (Cambridge) and Patti A. Quant (London): Defining regulation and control in complex, dynamic metabolic systems by experimental application of the top-down approach of metabolic control analysis: 381-388. [Abstract]

Theory: molecular control analysis

Guy C. Brown (Cambridge), Hans V. Westerhoff (Amsterdam) and Boris N. Kholodenko (Moscow): Molecular control analysis: control within proteins and molecular processes: 389-396. [Abstract]

Arthur R. Schulz (Indianapolis) and Janos Südi (Kiel): Control analysis of single enzyme sequences with abortive complexes and random substrate binding: 397-403. [Abstract]

Theory: biotechnological implications

Nestor Torres (Tenerife): Metabolic control analysis of the inhibitory feedback interaction: application to biotechnological processes: 405-410. [Abstract]

Hans V. Westerhoff (Amsterdam) and Douglas B. Kell (Aberystwyth): What biotechnologists knew all along..?? 411-420. [Abstract]

Control of particular systems

María Luz Cárdenas (Marseilles) and Albert Goldbeter (Brussels): The glucose-induced switch between glycogen phosphorylase and glycogen synthase in the liver: outlines of a theoretical approach: 421-426. [Abstract]

Albert K. Groen, Ronald P. J. Oude Elferink and Joseph M. Tager (Amsterdam): Control analysis of biliary lipid secretion: 427-436. [Abstract]

Ferenc Orosz, Beata G. Vértessy, Susan Hollán, Margit Horányi and Judit Ovádi (Budapest): Triosephosphate isomerase deficiency: predictions and facts: 437-447. [Abstract]

Mark Salter (Beckenham): Determination of the flux control coefficient of nitric oxide synthase for nitric oxide synthesis in discrete brain regions in vivo: 449-452. [Abstract]

Barbara E. Wright, Angelika Longacre and Jacqueline Reimers (Missoula): Models of metabolism in Rhizopus oryzae: 453-457. [Abstract]

Related information

Obituary notice

List of Henrik Kacser’s publications

Annotated list of Henrik Kacser’s publications

The following is an interesting article on the historical background of the work on dominance that could easily have appeared in the special issue if it had not already been commissioned by another journal: Peter D. Keightley (1996) A metabolic basis for dominance and recessivity Genetics 143, 621-625.