Theoretical Biology of Systems

This is the home page for the research group of Athel Cornish-Bowden and María Luz Cárdenas at the CNRS in Marseilles, now part of the group on Extremophile Metabolism directed by Marie-Thérèse Giudici-Orticoni.

Contents

• Members of the group
• Research interests
• Location
• Getting here
• Contact information
• Current publications
• Books from our group
• Research collaborations
• Metabolic control analysis links
• Invited participation in meetings

Members of the group

Research interests

Our recent publications are listed below. Complete publication lists are also available, arranged either by year of publication or under various broad headings, as follows:

1. Current or recent activities
   • Multienzyme systems: ACB; MLC
   • Metabolic simulation: ACB; MLC
   • Metabolic circularity and the nature of life: ACB; MLC
   • Enzyme kinetics: ACB; MLC
   • Mammalian hexokinases: MLC; ACB
2. Earlier research interests
   • Pepsin (ACB)
   • Binding of ligands to proteins (ACB)
   • Other experimental studies of enzymes: ACB; MLC
   • Evolution of macromolecules (ACB)
   • Nitrite reductase and nitrate reductase: ACB; MLC
   • Miscellaneous: ACB; MLC
3. Books from our group

A list of our most highly cited publications may be found on another page.

Location

Bioénergétique et Ingénierie des Protéines, Centre National de la Recherche Scientifique, 31 chemin Joseph-Aiguier, B.P. 71, 13402 Marseille Cedex 20, France

The laboratory Bioénergétique et Ingénierie des Protéines (BIP, CNRS UMR 7281) is directed by Dr Marie-Thérèse Giudici-Orticoni and is a component unit of the Groupe de Laboratoires de Marseille du CNRS (Marseilles Group of CNRS Laboratories).

Getting here

A separate web page gives suggestions on how to reach the CNRS.

Contact information

• Telephone: + 33 491 16 41 38
• Fax: + 33 491 16 45 78
•  NEW!  Email (AJCB): acornish@;imm.cnrs.fr  CHANGED! 
  
•  NEW!  Email (MLC): cardenas@imm.cnrs.fr  CHANGED! 
• Postal delivery: CNRS-BIP, 31 chemin Joseph-Aiguier, B.P. 71, 13402 Marseille Cedex 20, France
• Other delivery: CNRS-BIP, 31 chemin Joseph-Aiguier, 13009 Marseille, France

Current publications

Complete lists may be found here (AJCB) or here (MLC). This list includes only articles in press or recently published..

2012

 NEW!  G. Piedrafita, A. Cornish-Bowden, F. Morán & F. Montero (2012) Size matters: influence of stochasticity on the self-maintenance of a simple model of metabolic closure J. Theor. Biol. in press

2011

R. A. Alberty, A. Cornish-Bowden, R. N. Goldberg, G. G. Hammes, K. Tipton & H. V. Westerhoff (2011) Recommendations for terminology and databases for biochemical thermodynamics Biophys. Chem. 155, 89–203

M. L. Cárdenas & A. Cornish-Bowden (2011) Metabolism in Encyclopedia of Astrobioloogy (ed. M. Gargaud) Springer-Verlag, Berlin pp. 1016–1017 [PDF file: please enquire]

A. Cornish-Bowden & M. L. Cárdenas (2011) Enzyme in Encyclopedia of Astrobioloogy (ed. M. Gargaud) Springer-Verlag, Berlin pp. 499–500 [PDF file: please enquire]

A. Cornish-Bowden, M. L. Cárdenas & E. Lojou (2011) Reflections on energy conversion in biological and biomimetic systems in Functional Nanoscience (ed. M. G. Hicks & C. Kettner) Beilstein Institute, Frankfurt, pp. 129–142 [PDF file]

G. Curien, R. Dumas, A. Cornish-Bowden & M. L. Cárdenas (2011) Different contributions of the various isoenzymes to the flux in the aspartate-derived amino acid pathway in Arabidopsis thaliana in Experimental Standard Conditions of Enzyme Characterizations III (ed. M. G. Hicks & C. Kettner) Beilstein Institute, Frankfurt, pp. 107–121 [PDF file]

J.-C. Letelier, M. L. Cárdenas & A. Cornish-Bowden (2011) From L’Homme Machine to metabolic closure: steps towards understanding life J. Theor. Biol. 286, 100–113 [PDF file: please enquire]

2010

R. Apweiler, R. Armstrong, A. Bairoch, A. Cornish-Bowden, P. J. Halling, J.-H. S. Hofmeyr, C. Kettner, T. S. Leyh, J. Rohwer, D. Schomburg, C. Steinbeck & K. Tipton (2010) A large-scale protein-function database Nat. Chem. Biol. 6, 785 [PDF file] . This letter is the subject of an editorial in Nat. Chem. Biol. 6, 783

M. L. Cárdenas (2010) Prix Nobel de Médecine et Physiologie 2009: les origines d’une découverte peuvent être lointaines Regard sur la Biochimie, April 2010, 3–4

M. L. Cárdenas, J.-C. Letelier, C. Gutierrez, A. Cornish-Bowden & J. Soto-Andrade (2010) Closure to efficient causation, computability and artificial life J. Theor. Biol. 263, 79–92 [PDF file: please enquire]

A. Cornish-Bowden (2010) Kinetics, Enzymes in The Wiley Encyclopedia of Industrial Biotechnology (ed. A. Seidel), 5, 3047–3060

A. Cornish-Bowden & M. L. Cárdenas (2010) Specificity of non-Michaelis–Menten enzymes: necessary information for analyzing metabolic pathways J. Phys. Chem. B 114, 16209–16213 [PDF file]

A. Cornish-Bowden, R. N. Goldberg & G. G. Hammes (2010) Professor Robert A. Alberty — a legacy of excellence J. Phys. Chem. B 114, 16045–16046 [PDF file]

S. Jaramillo, R. Honorato-Zimmer, U. Pereira, D. Contreras, B. Reynaert, V. Hernández, J. Soto-Andrade, M. L. Cárdenas, A. Cornish-Bowden & J. C. Letelier (2010) (M,R) systems and RAF sets: common ideas, tools and projections Proc. ALIFE XII Conf. (Proceedings of the ALIFE XII Conference, Odense Denmark, August 2010), pp. 94–124 [PDF file]

G. Piedrafita, F. Montero, F. Morán, M. L. Cárdenas & A. Cornish-Bowden (2010) A simple self-maintaining metabolic system: robustness, autocatalysis, bistability PLoS Comp. Biol. 6, e1000872 [PDF file]

2009

M. L. Cárdenas (2009) La théorie de l’évolution: plus importante que jamais après 150 ans Regard sur la Biochimie, May 2009, 7–8

M. L. Cárdenas (2009) ¿Por qué aún cuesta tanto aceptar la teoría de la evolución? Algunas reflexiones (Why so much difficulty for accepting the theory of evolution? Some reflections) SEBBM No. 160 (June 2009), 14–16 [PDF file]

M. L. Cárdenas (2009) Henri-Géry Hers (1923–2008) Regard sur la Biochimie, May 2009, 8–9

A. Cornish-Bowden & M. L. Cárdenas (2009) Catalysis at the origin of life viewed in the light of the (M,R) systems of Robert Rosen in Systems Chemistry (ed. M. G. Hicks & C. Kettner) Beilstein Institute, Frankfurt, pp. 21–32

G. Curien, O. Bastien, M. Robert-Genthon, A. Cornish-Bowden, M. L. Cárdenas & R. Dumas (2009) Understanding regulation of aspartate metabolism with a model based on measured kinetic parameters Mol. Syst. Biol. 5, 271 [PDF file] & Supplementary data (PDF file)

2008

A. Cornish-Bowden (2008) Reinhart Heinrich (1946–2006): an annotated bibliography J. Theor. Biol. 252, 379—387 [Text in full]

A. Cornish-Bowden (2008) Jeremy Randall Knowles (1935–2008) The Biochemist 30(3), 46–47 [PDF file]

A. Cornish-Bowden (2008) Monitoring the energy status of a living organism in real time J. Biosci. 33, 629–630 [PDF file]

A. Cornish-Bowden & M. L. Cárdenas (2008) Self-organization at the origin of life J. theor. Biol. 252, 411–418

2007

A. Cornish-Bowden (2007) Daniel E. Koshland, Jr (1920–2007) The Biochemist 29(6), 42–43 [PDF file]

A. Cornish-Bowden (2007) Reinhart Heinrich (1946–2006) The Biochemist 29(1), 47, reprinted in J. Theor. Biol. 252, 377–378 (2008) [Text in full]

A. Cornish-Bowden (2007) Biochemistry textbooks: are they getting better? The Biochemist 29(5), 16–18 [PDF file]

Books from our Group

Athel Cornish-Bowden (1995) Analysis of Enzyme Kinetic Data, Oxford University Press, Oxford

María Luz Cárdenas (1995) "Glucokinase": its Regulation and Role in Liver Metabolism, R. G. Landes, Austin, Texas

Athel Cornish-Bowden, ed. (1997) New Beer in an Old Bottle: Eduard Buchner and the Growth of Biochemical Knowledge, Universitat de València, Valencia

Athel Cornish-Bowden (1999) Basic Mathematics for Biochemists (2nd edn.), Oxford University Press, Oxford

Athel Cornish-Bowden & María Luz Cárdenas (2000) Technological and Medical Implications of Metabolic Control Analysis, Kluwer Academic Publishers, Dordrecht, The Netherlands

Athel Cornish-Bowden (2004) Fundamentals of Enzyme Kinetics (3rd edn.), Portland Press, London

Athel Cornish-Bowden (2004) The Pursuit of Perfection Oxford University Press, Oxford

Athel Cornish-Bowden, Marc Jamin & Valdur Saks (2005) Cinétique Enzymatique (in French), EDP Sciences, Paris

Current or recent research collaborations

• Gilles Curien (Grenoble, France): Regulation of aspartate metabolism in Arabidopsis
• Laboratoire de Biotechnologie de l’Environnement (Narbonne, France),
  Marie-Thérèse Giudici-Orticoni (this laboratory, Marseilles, France) and
  Laboratoire d’Ingénierie des Systèmes Biologiques et des Procédés (Toulouse, France):
  ANR Project InGEcoH (Ecological engineering of microbial ecosystems producing biohydrogen by dark fementation)
• Jan-Hendrik Hofmeyr (Stellenbosch, South Africa): Theory of metabolic regulation
• Juan-Carlos Letelier, Jorge Soto-Andrade (Santiago, Chile): (M,R) systems
• Enrique Meléndez-Hevia (Tenerife, Spain): Aspects of metabolism
• Francisco Montero, Federico Morán (Madrid, Spain): (M,R) systems

Metabolic control analysis links

This section provides a link to a page of general information on metabolic control analysis.