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Technological and Medical Implications of
Metabolic Control Analysis

This page describes the book Technological and Medical Implications of Metabolic Control Analysis, edited by Athel Cornish-Bowden and María Luz Cárdenas, published by Kluwer Academic Publishers (2000): ISBN 0-7923-6188-1

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General description

This book contains the proceedings of a NATO Advanced Research Workshop held at Visegrád, Hungary, in April 1999. Information (no longer being actively updated) about the Workshop may be found elsewhere.

Publication details

Published by Kluwer Academic Publishers, Dordrecht, 2000

Price in euros*140.50 EUR54.50 EUR
Price in US dollars*165.00 USD64.00 USD
Price in UK pounds*100.00 GBP40.00 GBP

*Prices given are up to date on Thursday 11 April 2002, but may change without notice. Please check the Publisher’s page for current information.

Sold and distributed in the Americas by Kluwer Academic Publishers, 101 Philip Drive, Norwell, Massachusetts 02061, and in all other countries by Kluwer Academic Publishers, P.O. Box 322, 3300 AH Dordrecht, The Netherlands.



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  1. Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems
  2. Imposing Discipline: Manipulation of Organisms for Technological Ends
  3. Understanding Health and Disease: Why Organisms Behave as they do
  4. Taking Aim: Use of Metabolic Models to Identify Drug Targets
  5. Facing Reality: Not just a Bag of Enzymes
  6. Thinking about Metabolism: the Relationship between Control and Regulation
  7. Taking Stock: Control Analysis in the Context of Metabolic Regulation


1. Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems

1. Douglas B. Kell and Pedro Mendes
Snapshots of systems: metabolic control analysis and biotechnology in the post-genomic era, pp. 3–25

2. Johann M. Rohwer, Brett G. Olivier and Jan-Hendrik S. Hofmeyr
Moiety conservation and flux enhancement, pp. 27–32

3. Luis Acerenza
On the universality of the universal method, pp. 33–37

2. Imposing Discipline: Manipulation of Organisms for Technological Ends

4. James E. Bailey
Life is complicated, pp. 41–47

5. James C. Liao
Regulation and redirection of metabolism: incorporating regulatory information in flux calculation, pp. 49–56

6. Stefan Schuster, Thomas Dandekar, Klaus Mauch, Matthias Reuss and David Fell
Recent developments in metabolic pathway analysis and their potential implications for biotechnology and medicine, pp. 57–66

7. Jacky L. Snoep, Coen C. van der Weijden, Heidi W. Andersen, Hans V. Westerhoff and Peter R. Jensen
Quantifying the importance of regulatory loops in homeostatic control mechanisms: hierarchical control of DNA supercoiling, pp. 67–72

8. Johann M. Rohwer and Jan-Hendrik S. Hofmeyr
An integrated approach to the analysis of the control and regulation of cellular systems, pp. 73–79

3. Understanding Health and Disease: Why Organisms Behave as they do

9. Peter Duesberg, Ruhong Li, Charlotte Rausch, Andreas Willer, Alwin Kraemer, George Yerganian, Ruediger Hehlmann and David Rasnick
Mechanism of carcinogenesis by polycyclic aromatic hydrocarbons: aneuploidy precedes malignant transformation and occurs in all cancers, pp. 83–98

10. David Rasnick and Peter H. Duesberg
Metabolic control analysis shows how aneuploidy causes cancer, pp. 99–107

11. Loranne Agius, Susan Aiston and Christopher B. Newgard
The control strength of glucokinase in hepatocytes: a predictor of metabolic defects in maturity onset diabetes of the young, Type 2, pp. 109–115

12. Costantino Salerno and Carlo Crifò
Metabolic distress associated with impaired control by alternate substrates: two examples taken from purine metabolism, pp. 117–123

13. Bernard Korzeniewski
Regulation of ATP supply in muscle: implications for importance of flux control coefficients and for the genesis of mitochondrial myopathies, pp. 125–130

14. Martin D. Brand and Edward K. Ainscow
Regulation of energy metabolism in hepatocytes, pp. 131–138

15. Philip W. Kuchel and Peter J. Mulquiney
Combined NMR experimental and computer-simulation study of 2,3-bisphosphoglycerate metabolism in human erythrocytes, pp. 139–145

4. Taking Aim: Use of Metabolic Models to Identify Drug Targets

16. Pedro Mendes
Computational approaches to the study of biochemical pathways and metabolic control, pp. 149–155

17. Barbara M. Bakker, Paul A. M. Michels, Michael C. Walsh, Fred R. Opperdoes and Hans V. Westerhoff
Using metabolic control analysis to improve the selectivity and effectiveness of drugs against parasitic diseases, pp. 157–164

18. Athel Cornish-Bowden and Robert Eisenthal
Computer simulation as a tool for studying metabolism and drug design, pp. 165–172

19. Marta Cascante, Begoña Comin, Joan Boren, Badr Raïs, Josep J. Centelles, Joaquim Puigjaner, Wai-Nang Paul Lee and Laszlo G. Boros
Application of metabolic control analysis to the design of a new strategy for cancer therapy, pp. 173–180

5. Facing Reality: Not just a Bag of Enzymes

20. Károly Liliom, Gábor Wágner, Ferenc Orosz, János Kovács and Judit Ovádi
Implications of cytoarchitectural analysis, pp. 183–190

21. Kevin M. Brindle and Peter M. Haggie
Probing the cell interior with NMR spectroscopy, pp. 191–198

22. Natalie S. Cohen, Chia-Wei Cheung and Luisa Raijman
Metabolite channelling and protein–protein interactions in the pathway of urea synthesis, pp. 199–206

23. Juan C. Ferrer, Susanna Baqué, Josep M. Fernández-Novell, Mar García-Rocha and Joan J. Guinovart
Intracellular distribution of glycogen synthase: an additional regulatory mechanism of glycogen metabolism?, pp. 207–214

24. Murray P. Deutscher
Supramolecular organization and substrate channelling in the mammalian translation system, pp. 215–221

25. David Sullivan, Norma Slepecky and Nicholas Fuda
Analysis of co-localization of glycolytic enzymes in flight muscle and its relation to muscle function in Drosophila, pp. 223–231

6. Thinking about Metabolism: The Relationship between Control and Regulation

26. Hans V. Westerhoff, Bas Teusink, Femke Mensonides, Karin A. Reijenga, Eugenia Esgalhado, Boris N. Kholodenko, Oscar J. Somsen, Wally C. van Heeswijk, Fred C. Boogerd and Jacky L. Snoep
Metabolic control from the back benches: biochemistry towards biocomplexity, pp. 235–242

27. Victoria Guixé
Physiological consequences of a non-regulated mutant phosphofructokinase in Escherichia coli, pp. 243–250

28. Stefan E. Szedlacsek
Time-dependent or steady-state control of metabolic systems?, pp. 251–258

29. Simon Thomas and David A. Fell
Multisite modulation in the control of glycolysis: balance of supply and demand?, pp. 259–266

30. David A. Fell and Simon Thomas
Exercising control when control is distributed, pp. 267–274

31. Luis Acerenza
Metabolic control design: implications and applications, pp. 275–282

32. Christoph Giersch
Determining elasticities in situ, pp. 283–288

33. María Luz Cárdenas
Coordination and homeostasis in the response to multiple signals: role of metabolic cascades, pp. 289–298

34. Jan-Hendrik S. Hofmeyr, Brett G. Olivier and Johann M. Rohwer
Putting the cart before the horse: designing a metabolic system in order to understand it, pp. 299–308

35. Reinhart Heinrich
Predicting the structural design of metabolic pathways: an evolutionary approach, pp. 309–317

36. Enrique Meléndez-Hevia, Ruth Meléndez and Enric I. Canela
Glycogen structure: an evolutionary view, pp. 319–326

7. Taking Stock: Control Analysis in the Context of Metabolic Regulation

37. Louis Hue
Control and regulation, pp. 329–337

38. Paul A. Srere
Metabolic control and metabolons in the millennium, pp. 339–345

Athel Cornish-Bowden
In memoriam: Paul Srere, 1925–1999, pp. 347–349