María Luz Cárdenas-Cerda

1. Identification

Personal History: Born in Santiago, Chile; married to Dr. Athel Cornish-Bowden, one daughter.

Present Position: Senior Scientist, CNRS, Marseilles, France

Postal address: Bioénergétique et Ingénierie des Protéines, Centre National de la Recherche Scientifique, 31 chemin Joseph-Aiguier, B.P. 71, 13402 Marseille Cedex 20, France.

Telephone: +33 491 16 41 38 (lab)
Fax: +33 491 16 40 97

Email (MLC): cardenas@imm.cnrs.fr CHANGED!

2. University Education

Undergraduate: University of Chile, Faculty of Chemistry and Pharmacy, School of Biochemistry (1962–1965). Faculty of Sciences, Department of Chemistry (1966–1969). Thesis: Studies on the Interaction between Threonyl-tRNA Synthetase and Threonine tRNA; adviser: Prof. Catherine C. Allende.

Post-graduate: University of Chile, Faculty of Sciences, Post-graduate Program. Thesis: Glucokinase, A Monomeric enzyme with Kinetic Cooperativity; adviser: Prof. Hermann Niemeyer.

3. Academic Degrees

1970 Licenciado en Ciencias with speciality in Chemistry, University of Chile; with Highest Distinction

1982 Doctor en Ciencias with speciality in Biology, University of Chile

4. Honours

Hermann Niemeyer Professor, Facultad de Ciencias, Universidad de Chile, Santiago, Chile, 1993.

2002. Elected corresponding member of the Academia Chilena de Ciencias.

5. Field of Research

Biochemistry; Enzymology; Kinetics; Metabolic regulation; Interconvertible enzyme cascades as switches; Mammalian hexokinases; Multi-enzyme systems; Metabolic simulation; Metabolic circularity and the nature of life

6. Scientific Societies

Sociedad de Biología de Chile; Sociedad de Bioquímica de Chile; Société Française de Biochimie et de Biologie Moléculaire (France); The Biochemical Society (UK); Sociedad Española de Bioquímica (Spain).

2005–present: Member of the Conseil d’Administration of the Société Française de Biochimie et de Biologie Moléculaire.

7. Positions held

CHILE

1965–1970

University of Chile, Department of Basic Sciences, School of Veterinary Medicine, Part-time Lecturer and Laboratory Supervisor (in charge of laboratory courses in cell biology and genetics to students of the 1st year of veterinary medicine).

1970–1972

University of Chile, Assistant Professor and Laboratory Supervisor, Department of Basic Sciences, School of Veterinary Medicine (full-time); School of Human Medicine (part-time).

1973–1975

University of Chile, Assistant Professor and Laboratory supervisor, Biology section, School of Human Medicine (full-time).

During the period 1970–1975 my teaching experience included cell biology and genetic couses for students of Medicine (1st year, 25–50 students) and veterinary medicine (1st year, 160–250 students). My teaching responsibility was related especially to the sections of the course concerned with the molecular components of cells and on bioenergetics, and included lectures, demonstrating and examining.

1975–1988

Associate Professor, Section of Biochemistry, Department of Biology, Faculty of Sciences. (During the period 1981 to 1985 the Faculty was fused with the Faculty of Pharmacy under the name of Faculty of Basic Sciences and Pharmacy)

In this period my teaching experience involved participation in undergraduate and postgraduate courses in the area of Biochemistry as mentioned below (Section 7). each course was taught for one semester (i.e. 18 weeks) each year.

ENGLAND

1982–1985

Honorary Research Fellow, University of Birmingham, Department of Biochemistry. Post-doctoral training in the laboratory of Dr. Ian P. Trayer. Grant-in-Aid from the British Council.

FRANCE

1987–1988

Maître de Conférences 1^ère classe. University of Aix-Marseille II (now University of the Mediterranean), Faculty of Sciences, Luminy.

1988–2009

Chargé de Recherche 1^ère Classe (tenured), Centre National de Recherche Scientifique (CNRS), Marseille.

2009–present

Senior Scientist, Centre National de Recherche Scientifique (CNRS), Marseille.

8. Editorial Board

2004–present

Member of the Editorial Board of the Journal of Biosciences, Bangalore, India

9. International Committee

2011–2012

Member of the 22nd IUBMB and 37th FEBS Advisory Board (Seville, 2012)

10. Thesis Supervision

Maria Lila Vera (1981) Glucose Phosphorylating enzymes of Rat Intestinal Mucosa. Master in enzymology. University of Chile

Alejandro Reyes (1982) Glucose Phosphorylating Isozymes in Hepatocytes and Non-parenchymal Cells Isolated from Rat Liver. Licenciatura degree, Faculty of Basic Sciences and Pharmacy. University of Chile.

Naima Chajri (1991) Molecular Characterisation of glyceraldehyde-3-phosphate dehydrogenase from spinach chloroplasts. Diplome d’Etudes Approfondies d’enzymologie (DEA), Universities of Aix-Marseille II and Paris XI.

Christophe Chevillard (1991) Purification and kinetics studies of glyceraldehyde-3-phosphate dehydrogenase of spinach chloroplasts. Diplome d’Etudes Approfondies d’enzymologie (DEA), Universities of Aix-Marseille II and Paris XI.

11. Publications

Publications from the past ten years are listed here. A complete list is given on a separate page. Invited contributions are indicated by an asterisk (*) next to the name of the person invited.

*M. L. Cárdenas (2000) Coordination and homeostasis in the response to multiple signals: Role of metabolic cascades, pp. 289–298 in Technological and Medical Implications of Metabolic Control Analysis (ed. A. Cornish-Bowden & M. L. Cárdenas), Kluwer Academic Publishers, Dordrecht, The Netherlands [Text in full]

M. L. Cárdenas & A. Cornish-Bowden (2000) Metabolic analysis in drug discovery Science 288, 618–619 [Text in full]

*A. Cornish-Bowden & M. L. Cárdenas (2000) From genome to cellular phenotype — a role for metabolic flux analysis?, Nature Biotechnol. 18, 267–268 [Text in full]

A. Cornish-Bowden & M. L. Cárdenas (2000) Irreversible Reactions in Metabolic Simulations: how Reversible is Irreversible? in Animating the Cellular Map (ed.. J.-H. S. Hofmeyr, J. M. Rohwer & J. L. Snoep) Stellenbosch University Press, Stellenbosch, pp. 65–71 [Text in full]

A. Cornish-Bowden & M. L. Cárdenas (2000) Life on earth: probability of a cosmic origin, The Biochemist 22(2), 35–38 [Text in full]

M. L. Cárdenas (2001) The competition plot: a kinetic method to assess whether an enzyme that catalyzes multiple reactions does so at a unique site Methods 24, 175–180 [Text in full]

*M. L. Cárdenas & A. Cornish-Bowden (2001) Haciendo hablar a los genes Diario de Sevilla, 24 July 2001, pp. 38–39 (in Spanish) [Text in full]

*A. Cornish-Bowden & M. L. Cárdenas (2001) Silent genes given voice, Nature 409, 571–572 [Text in full]

*A. Cornish-Bowden & M. L. Cárdenas (2001) Complex networks of interactions connect genes to phenotypes Trends Biochem. Sci. 26, 463–465 [Text in full]

A. Cornish-Bowden & M. L. Cárdenas (2001) Information transfer in metabolic pathways: effects of irreversible steps in computer models, Eur. J. Biochem. 268, 6616–6624 [Text in full]

A. Cortés, M. Cascante, M. L. Cárdenas & A. Cornish-Bowden (2001) Relationships between inhibition constants, inhibitor concentrations for 50% inhibition and types of inhibition: new ways of analysing data Biochem. J. 357, 263–268 [Text in full]

M. L. Cárdenas, F. Ortega, M. Cascante & A. Cornish-Bowden (2002) Modulation of metabolite concentrations with no net effect on fluxes, Mol. Biol. Rep.29, 17–20 [Text in full]

A. Cornish-Bowden & M. L. Cárdenas (2002) Metabolic balance sheets, Nature 420, 129–130 [Text in full | PDF file]

A. Cornish-Bowden, J.-H. S. Hofmeyr & M. L. Cárdenas (2002) Stoicheiometric Analysis in Studies of Metabolism, Biochem. Soc. Trans. 30, 43–46 [Text in full]

*A. Cornish-Bowden & M. L. Cárdenas (2003) Metabolic analysis in drug design, C. R. Biologies 326, 509–515 [Abstract | PDF file]

*A. Cornish-Bowden & M. L. Cárdenas (2003) Metabolic analysis in drug design: complex, or just complicated? in Molecular Informatics: Confronting Complexity (ed. M. G. Hicks & C. Kettner) Beilstein Institute, Frankfurt, pp. 95–107

O. Monasterio & M. L. Cárdenas (2003) Kinetic studies of rat liver hexokinase D (glucokinase) in non-co-operative conditions show an ordered mechanism with MgADP as the last product to be released Biochem. J. 371, 29–38 [Abstract | PDF file]

*M. L. Cárdenas (2004) Comparative biochemistry of glucokinase in Glucokinase and Glycemic Disease: from Basics to Novel Therapeutics (ed. F. M. Matschinsky & M. A. Magnuson), Karger, Basle, pp. 31–41 [Introduction]

*A. Cornish-Bowden & M. L. Cárdenas (2004) Glucokinase: a monomeric cooperative enzyme with positive cooperativity in Glucokinase and Glycemic Disease: from Basics to Novel Therapeutics (ed. F. M. Matschinsky & M. A. Magnuson), Karger, Basle, pp. 125–134 [Introduction]

*A. Cornish-Bowden, M. L. Cárdenas, J.-C. Letelier, J. Soto-Andrade & F. Guíñez Abarzúa (2004) Understanding the parts in terms of the whole Biol. Cell 96 713–717 [Abstract | PDF file]

G. Chaufan, M. M. Corvi, L. C. San Martín de Viale, M. L. Cárdenas & M. C. Ríos de Molina (2005) Abnormal kinetic behavior of uroporphyrinogen decarboxylase obtained from rats with hexachlorobenzene-induced porphyria J. Biochem. Molec. Toxicol. 19, 19–24 [Abstract | PDF file]

*A. Cornish-Bowden & M. L. Cárdenas (2005) Systems biology may work when we learn to understand the parts in terms of the whole Biochem. Soc. Trans. 33, 516–519 [Text in full | PDF file]

*A. Cornish-Bowden & M. L. Cárdenas (2005) Handling equilibrium processes embedded in metabolic systems in The Chemical Theatre of Biological Systems (ed. M. G. Hicks & C. Kettner) Beilstein Institute, Frankfurt, pp. 185–195 [Abstract | PDF file]

J.-C. Letelier, J. Soto-Andrade, F. Guíñez Abarzúa, A. Cornish-Bowden & M. L. Cárdenas, (2004) Metabolic closure in (M,R systems in Artificial Life IX (ed. J. Pollack, M. Bedau, P. Husbands, T. Ikegami, R. A. Watson) MIT Press, Cambridge, Massachusetts, pp. 255–263.

J.-C. Letelier, T. Kuboyama, H. Yasuda, M. L. Cárdenas & A. Cornish-Bowden (2005) A self-referential equation, f(f) = f, obtained using the theory of (M,R,) systems: overview and applications in Algebraic Biology 2005 (ed. H. Anai and K. Horimoto) Universal Academy Press, Tokyo, pp. 115–126. [Abstract | PDF file]

J.-C. Letelier, J. Soto-Andrade, F. Guíñez Abarzúa, A. Cornish-Bowden & M. L. Cárdenas (2006) Organizational invariance and metabolic closure: analysis in terms of (M,R) systems J. theor. Biol. 238, 949–961 [Nearly complete text]

*M. L. Cárdenas (2007) ¿Quién era Hermann Niemeyer Fernández? (Who was Hermann Niemeyer Fernández?) SEBBM No. 153 (September 2007), 30–32

*A. Cornish-Bowden & M. L. Cárdenas (2007) Organizational invariance in (M,R) systems Chemistry and Biodiversity, 4, 2396–2406 [Text in full | PDF file]

A. Cornish-Bowden & M. L. Cárdenas (2007) Bringing chemistry to life: what does it mean to be alive? in Molecular Interactions: Bringing Chemistry to Life (ed. M. G. Hicks & C. Kettner) Beilstein Institute, Frankfurt, pp. 27–39

*A. Cornish-Bowden & M. L. Cárdenas (2007) Vertical integration from omics to the whole organism in Energy and Protein Metabolism and Nutrition (ed. I. Ortigues-Marty, N. Miraux & W. Brand-Williams) Wageningen Academic Publishers, Wageningen, pp. 463–472 [Text in full]

*A. Cornish-Bowden & *M. L. Cárdenas (2007) La amenaza del creacionismo para la enseñanza racional de la biología (The threat from creationism to the rational teaching of biology) SEBBM No. 153 (September 2007), 8–16 [Text in full]

*A. Cornish-Bowden, M. L. Cárdenas, J.-C. Letelier & J. Soto-Andrade (2007) Beyond reductionism: metabolic circularity as a guiding vision for a real biology of systems Proteomics, 7, 839–845 [Abstract | PDF file]

*A. Cornish-Bowden & M. L. Cárdenas (2007) The threat from creationism to the rational teaching of biology Biol. Res. 40, 113–122 [Text in full | PDF file]

*A. Cornish-Bowden & *M. L. Cárdenas (2008) Self-organization at the origin of life J. theor. Biol. 252, 411—418

*M. L. Cárdenas (2008) Homenaje al Profesor Gustavo Francisco Hoecker Salas, un pionero de la ciencia chilena. Recuerdos de un maestro An. Acad. Chil. Cienc. 10, 53–63

*M. L. Cárdenas (2009) La théorie de l’évolution: plus importante que jamais après 150 ans Regard sur la Biochimie, May 2009, 7–8

M. L. Cárdenas (2009) ¿Por qué aún cuesta tanto aceptar la teoría de la evolución? Algunas reflexiones (Why so much difficulty for accepting the theory of evolution? Some reflections) SEBBM No. 160 (June 2009), 14–16 [PDF file]

*M. L. Cárdenas (2009) Henri-Géry Hers (1923–2008) Regard sur la Biochimie, May 2009, 8–9

*A. Cornish-Bowden & M. L. Cárdenas (2009) Catalysis at the origin of life viewed in the light of the (M,R) systems of Robert Rosen in Systems Chemistry (ed. M. G. Hicks & C. Kettner) Beilstein Institute, Frankfurt, pp. 21–32

G. Curien, O. Bastien, M. Robert-Genthon, A. Cornish-Bowden, M. L. Cárdenas & R. Dumas (2009) Understanding regulation of aspartate metabolism with a model based on measured kinetic parameters Mol. Syst. Biol. 5, 271 [PDF file] & Supplementary data (PDF file)

E. Meléndez-Hevia, P. de Paz-Lugo, A. Cornish-Bowden & M. L. Cárdenas (2009) A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis J. Biosci. 34, 853–872 [PDF file]

*M. L. Cárdenas (2010) Prix Nobel de Médecine et Physiologie 2009: les origines d’une découverte peuvent être lointaines Regard sur la Biochimie, April 2010, 3–4

M. L. Cárdenas, J.-C. Letelier, C. Gutierrez, A. Cornish-Bowden & J. Soto-Andrade (2010) Closure to efficient causation, computability and artificial life J. Theor. Biol. 263, 79–92 [PDF file: please enquire]

A. Cornish-Bowden & M. L. Cárdenas (2010) Specificity of non-Michaelis–Menten enzymes: necessary information for analyzing metabolic pathways J. Phys. Chem. B 114, 16209–16213 [PDF file]

S. Jaramillo, R. Honorato-Zimmer, U. Pereira, D. Contreras, B. Reynaert, V. Hernández, J. Soto-Andrade, M. L. Cárdenas, A. Cornish-Bowden & J. C. Letelier (2010) (M,R) systems and RAF sets: common ideas, tools and projections Proc. ALIFE XII Conf. (Proceedings of the ALIFE XII Conference, Odense Denmark, August 2010), pp. 94–124 [PDF file]

G. Piedrafita, F. Montero, F. Morán, M. L. Cárdenas & A. Cornish-Bowden (2010) A simple self-maintaining metabolic system: robustness, autocatalysis, bistability PLoS Comp. Biol. 6, e1000872 [PDF file]

*M. L. Cárdenas & A. Cornish-Bowden (2011) Metabolism in Encyclopedia of Astrobioloogy (ed. M. Gargaud) Springer-Verlag, Berlin pp. 1016–1017 [PDF file: please enquire]

*A. Cornish-Bowden & M. L. Cárdenas (2011) Enzyme in Encyclopedia of Astrobioloogy (ed. M. Gargaud) Springer-Verlag, Berlin pp. 499–500 [PDF file: please enquire]

A. Cornish-Bowden, M. L. Cárdenas & E. Lojou (2011) Reflections on energy conversion in biological and biomimetic systems in Functional Nanoscience (ed. M. G. Hicks & C. Kettner) Beilstein Institute, Frankfurt, pp. 129–142 [PDF file]

G. Curien, R. Dumas, A. Cornish-Bowden & *M. L. Cárdenas (2011) Different contributions of the various isoenzymes to the flux in the aspartate-derived amino acid pathway in Arabidopsis thaliana in Experimental Standard Conditions of Enzyme Characterizations III (ed. M. G. Hicks & C. Kettner) Beilstein Institute, Frankfurt, pp. 107–121 [PDF file]

J.-C. Letelier, M. L. Cárdenas & *A. Cornish-Bowden (2011) From L’Homme Machine to metabolic closure: steps towards understanding life J. Theor. Biol. 286, 100–113 [PDF file: please enquire]

12. Books

Cornish-Bowden, A. & Cárdenas, M. L. (eds.) (1990) Control of Metabolic Processes (Proceedings of a NATO Advanced Research Workshop held at Il Ciocco, Italy, 1989), Plenum, New York

*M. L. Cárdenas (1995) Glucokinase: its regulation and role in liver metabolism, R. G. Landes Co, Austin

Cornish-Bowden, A. & Cárdenas, M. L. (eds.) (2000) Technological and Medical Implications of Metabolic Control Analysis (Proceedings of a NATO Advanced Research Workshop held at Visegrád, Hungary, 1999) Kluwer Academic Publishers, Dordrecht, The Netherlands

A. Cornish-Bowden & M. L. Cárdenas (2001) Methods 24 (guest editors of an issue on modern methods in kinetics)

13. Invited participation in recent or forthcoming meetings

A list may be found on another page.