This page is the introduction to a series of pages based on Chapter 12 (Kinetics of Multi-enzyme Systems

) of
Fundamentals of Enzyme Kinetics (3rd edition, 2004).

These pages are based closely on Chapter 12 of Fundamentals of Enzyme Kinetics (3rd edition, Athel Cornish-Bowden, 2004, Portland Press, London). More information about the book can be found elsewhere. In preparing this hypertext version nearly all of the equations have been embedded as GIF images, to allow more exact typography than would otherwise be possible. To minimize the cost in slow loading times, however, many algebraic expressions in the text have been left as text.

The series of pages was completely revised in April 2005 in order to take account of the 3rd edition of the book. Although
much of the chapter is unchanged from the 2nd edition (1995), there are some additions. **As the revision may have resulted
in the appearance of new errors, missing algebraic expressions, incorrect links, etc. I should be grateful if you could
let me know of any that you notice.**

Most of the pages in this series are also available in French.
*La plupart des pages dans cette série
sont disponibles aussi en français.*

- 12.1. Enzymes in their physiological contexts
- 12.2. Metabolic control analysis
- 12.3. Elasticities
- 12.4. Control coefficients
- 12.5. Summation relationships
- 12.6. Relationships between elasticities and control coefficients
- 12.6.1 Connectivity properties
- 12.6.2 Control coefficients in a three-step pathway
- 12.6.3 Expression of summation and connectivity relationships in matrix form
- 12.6.4 Connectivity relationship for a metabolite not involved in feedback
- 12.6.5 The flux control coefficient of an enzyme for the flux through its own reaction

- 12.7. Response coefficients: the partitioned response
- 12.8. Control and regulation
- 12.9. Mechanisms of regulation
- 12.10. Computer modelling of metabolism
- Problems