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Publications by Athel Cornish-Bowden

This page lists the publications of Athel Cornish-Bowden on multienzyme systems, apart from those on metabolic simulation (1986–present).

H: Kinetics of multienzyme systems

(a) Metabolic control analysis (research papers)

Ha1. A. Cornish-Bowden (1989) Metabolic control theory and biochemical systems theory: different objectives, different assumptions, different results J. Theor. Biol. 136, 365–377 [ Download PDF ]

Ha2. J.-H. S. Hofmeyr & A. Cornish-Bowden (1991) Quantitative assessment of regulation in metabolic systems Eur. J. Biochem. 200, 223–236 [104 citations in total; 4.5 per year between 1991 and 2014] [ Download PDF ]

Ha3. A. Cornish-Bowden & J.-H. S. Hofmeyr (1994) Determination of control coefficients in intact metabolic systems, Biochem. J. 298, 367–375 [ Download PDF ]

Ha4. A. Cornish-Bowden, J.-H. S. Hofmeyr & M. L. Cárdenas (1995) Strategies for manipulating metabolic fluxes in biotechnology Bioorg. Chem. 23, 439–449 [ Download PDF ]

Ha5. C. Giersch & A. Cornish-Bowden (1996) Extending double modulation: combinatorial rules for identifying the modulations necessary for determining elasticities in metabolic pathways, J. Theor. Biol. 182, 361–369 [ Download PDF ]

Ha6. J.-H. S. Hofmeyr & A. Cornish-Bowden (1996) Co-response analysis: a new strategy for experimental metabolic control analysis, J. Theor. Biol. 182, 371–380 [ Download PDF ]

Ha7. L. Acerenza & A. Cornish-Bowden (1997) Generalization of the double-modulation method for in situ determination of elasticities, Biochem. J. 327, 217–223 [ Download PDF ]

Ha8. P. de Atauri, R. Curti, J. Puigjaner, A. Cornish-Bowden & M. Cascante (1999) Advantages and disadvantages of aggregating fluxes into synthetic and degradative fluxes when modelling metabolic pathways, Eur. J. Biochem. 265, 671–679 [ Download PDF ]

Ha9. J.-H. S. Hofmeyr & A. Cornish-Bowden (2000) Regulating the cellular economy of supply and demand FEBS Lett. 476, 47–51 [ Download PDF ]

Ha10. A. Cornish-Bowden, J.-H. S. Hofmeyr & M. L. Cárdenas (2002) Stoicheiometric analysis in studies of metabolism, Biochem. Soc. Trans. 30, 43–46 [ Download PDF ]

Ha11. A. Cornish-Bowden & J.-H. S. Hofmeyr (2002) The role of stoicheiometric analysis in studies of metabolism: an example, J. theor. Biol. 216, 179–191 [ Download PDF ]

Ha12. M. L. Cárdenas, F. Ortega, M. Cascante & A. Cornish-Bowden (2002) Modulation of metabolite concentrations with no net effect on fluxes, Mol. Biol. Rep. 29, 17–20 [ Download PDF ]

Ha13. A. Cornish-Bowden & M. L. Cárdenas (2003) Metabolic analysis in drug design, in Modelling and Simulation of Biological Processes in the Context of Genomics (Proceedings of the Autrans Seminar, ed. P. Amar, F. Képès, V. Norris and P. Traqui), pages 57–65 [ Download PDF ]

Ha14. A. Cornish-Bowden & M. L. Cárdenas (2003) Metabolic analysis in drug design, C. R. Biologies 326, 509–515 [ Download PDF ]

(b) Dominance and recessivity

Hb1. A. Cornish-Bowden (1987) Dominance is not inevitable J. Theor. Biol. 125, 333–338 [ Download PDF ]

Hb2. A. Cornish-Bowden & V. Nanjundiah (2006) The basis of dominance in The Biology of Genetic Dominance (ed. R. A. Veitia) Landes Bioscience, Georgetown, Texas, pp. 1–16 [ Download PDF ]

(c) Interconvertible enzymes

Hc1. M. L. Cárdenas & A. Cornish-Bowden (1988) Importance de l’inhibition incompétitive dans les cascades enzymatiques (Importance of uncompetitive inhibition in enzyme cascades) in Contrôle du Métabolisme (ed. J.-P. Mazat & C. Reder), pp. 43–52, Bordeaux (in French)

Hc2. M. L. Cárdenas & A. Cornish-Bowden (1989) Characteristics necessary for an interconvertible enzyme cascade to give a highly sensitive response to an effector Biochem. J. 257, 339–345 [ Download PDF ]

Hc3. M. L. Cárdenas & A. Cornish-Bowden (1990) Properties needed for the enzymes of an interconvertible cascade to generate a highly sensitive response in Control of Metabolic Processes (ed. A. Cornish-Bowden & M. L. Cárdenas) pp. 195–207, Plenum Press, New York [ Download PDF ]

Hc4. A. Cornish-Bowden & S. E. Szedlacsek (1990) Very large response coefficients in interconvertible enzyme cascades Biomed. Biochim. Acta 49, 829–837 [ Download PDF ]

Hc5. S. E. Szedlacsek, M. L. Cárdenas & A. Cornish-Bowden (1992) Response coefficients of interconvertible enzyme cascades towards effectors that act on one or both modifier enzymes Eur. J. Biochem. 204, 807–813 [ Download PDF ]

(d) Metabolite channelling

Hd1. A. Cornish-Bowden (1991) Failure of channelling to maintain low concentrations of metabolic intermediates Eur. J. Biochem. 195, 103–108 [ Download PDF ]

Hd2. A. Cornish-Bowden (1991) How much effect on free metabolite concentrations does channelling have? J. Theor. Biol. 152, 39–40 [ Download PDF ]

Hd3. A. Cornish-Bowden & M. L. Cárdenas (1993) Channelling can affect concentrations of metabolic intermediates at constant net flux: artefact or reality? Eur. J. Biochem. 213, 87–92 [ Download PDF ]

Hd4. A. Cornish-Bowden (1994) Kinetic implications of metabolite channelling in β-oxidation, Biochem. Soc. Trans. 22, 451–454 [ Download PDF ]

Hd5. A. Cornish-Bowden & N. Kellershohn (1994) Metabolite channelling: does it allow lower concentrations of intermediates? pp. 319–323 in Biothermokinetics (ed. H. V. Westerhoff), Intercept, Andover (England)

Hd6. A. Cornish-Bowden (1997) Kinetic consequences of channelling in Channelling in intermediary metabolism (ed. L. Agius and H. S. A. Sherratt), Portland Press, London, pp. 53–70 [Introduction]

(e) Invited commentaries

He1. A. Cornish-Bowden & M. L. Cárdenas (2000) From genome to cellular phenotype — a role for metabolic flux analysis?, Nature Biotechnol. 18, 267–268 [ Download PDF ]

He2. A. Cornish-Bowden & M. L. Cárdenas (2001) Silent genes given voice Nature 409, 571–572 [ Download PDF ]

He3. A. Cornish-Bowden & M. L. Cárdenas (2001) Complex networks of interactions connect genes to phenotypes Trends Biochem. Sci. 26, 463–465 [ Download PDF ]

He4. A. Cornish-Bowden & M. L. Cárdenas (2002) Metabolic balance sheets, Nature 420, 129–130 [ Download PDF ]

He5. A. Cornish-Bowden (2013) Curbing the excesses of low demand Nature 500, 157–158: [ Download PDF ] [ DOI link ] 10.1038/nature12461

(f) Miscellaneous

Hf1. A. Cornish-Bowden (1986) Why is uncompetitive inhibition so rare? FEBS Lett. 203, 3–6 [ Download PDF ]

Hf2. A. Cornish-Bowden (1987) The time dimension in steady-state kinetics: a simplified representation of control coefficients Biochem. Educ. 15, 144–146 [ Download PDF ]

Hf3. A. Cornish-Bowden (1999) Enzyme kinetics from a metabolic perspective Biochem. Soc. Trans. 27, 281–284 [ Download PDF ]

Hf4. M. L. Cárdenas & A. Cornish-Bowden (2000) Metabolic analysis in drug discovery Science 288, 618–619 [Text in full]

Hf5. M. L. Cárdenas & A. Cornish-Bowden (2001) Haciendo hablar a los genes Diario de Sevilla, 24 July 2001, pp. 38–39 (in Spanish) [Text in full]

Hf6. A. Cornish-Bowden & J.-H. S. Hofmeyr (2005) Enzymes in context: kinetic characterization of enzymes for systems biology The Biochemist 27, 11–14 [ Download PDF ]

Hf7. E. Meléndez-Hevia, P. de Paz-Lugo, A. Cornish-Bowden & M. L. Cárdenas (2009) A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis J. Biosci. 34, 853–872 [ Download PDF ] [ DOI link ] 10.1007/s12038-009-0100-9

Hf8. A. Cornish-Bowden (2013) The physiological significance of negative cooperativity revisited J. Theor. Biol. 319, 144–147 [ DOI link ] 10.1016/j.jtbi.2012.12.010

(g) Metabolic control analysis (chapters etc.)

Hg1. J. A. Burns, A. Cornish-Bowden, A. K. Groen, R. Heinrich, H. Kacser, J. W. Porteous, S. M. Rapoport, T. A. Rapoport, J. W. Stucki, J. M. Tager, R. J. A. Wanders and H. V. Westerhoff (1985) Control analysis of metabolic systems Trends Biochem. Sci. 10, 16 [ Download PDF ]

Hg2. A. Cornish-Bowden (1990) The nature and role of theory in metabolic control in Control of Metabolic Processes (ed. A. Cornish-Bowden & M. L. Cárdenas) pp. 31–40, Plenum Press, New York [ Download PDF ]

Hg3. J.-H. S. Hofmeyr, A. Cornish-Bowden & J. M. Rohwer (1993) Taking enzyme kinetics out of control; putting control into regulation Eur. J. Biochem. 212, 833–837 [ Download PDF ]

Hg4. J.-H. S. Hofmeyr & A. Cornish-Bowden (1994) A control analysis of metabolic regulation, pp. 193–198 in Modern Trends in Biothermokinetics (ed. S. Schuster, M. Rigoulet, R. Ouhabi & J.-P. Mazat), Plenum Press, London

Hg5. A. Cornish-Bowden, M. L. Cárdenas & J.-H. S. Hofmeyr (1994) Vers une meilleure compréhension de la régulation métabolique Images Rech. [ Download PDF ]

Hg6. A. Cornish-Bowden (1994) Théorie du contrôle métabolique des systèmes biochimiques: considérations sur la nature de la théorie en biologie (Theory of metabolic control for biochemical systems: reflections on the nature of theory in biology) pp. 41–49 in La biologie théorique à Solignac (ed. H. Vérine), Polytechnica, Paris (in French)

Hg7. J.-H. S. Hofmeyr & A. Cornish-Bowden (1994) How should we quantify metabolic regulation? pp. 91–94 in What is controlling life? (ed. E. Gnaiger, F. N. Gellerich & M. Wyss), Innsbruck University Press, Innsbruck (Austria)

Hg8. A. Cornish-Bowden (1995) Metabolic control analysis in theory and practice Adv. Mol. Cell. Biol. 11, 21–64. [ Download PDF ]

Hg9. A. Cornish-Bowden (1995) Kinetics of Multi-Enzyme Systems, in Biotechnology, a Comprehensive Treatise (2nd edn., ed. H.-J. Rehm & G. Reed), Springer–Verlag, Weinheim (Germany), vol. 9, pp. 121–136

Hg10. J.-H. S. Hofmeyr & A. Cornish-Bowden (1996) Mathematical description of regulation in numerical systems: the regulatory potential, pp. 3305–3310 in World Congress of Nonlinear Analysts ’92 (ed. V. Lakshmikantham), Walter de Gruyter, Berlin

Hg11. J.-H. S. Hofmeyr & A. Cornish-Bowden (1996) Predicting metabolic pathway kinetics with control analysis, pp. 155–158 in BioThermoKinetics of the Living Cell (ed. H. V.Westerhoff, J. L.Snoep, J. E.Wijker, F. E. Sluse and B. N. Kholodenko), BioThermoKinetics Press, Amsterdam.

Hg12. A. Cornish-Bowden (1997) Vers une meilleure compréhension de la régulation metabolique (Towards a better understanding of metabolic regulation) pp. 15–25 in Pharmacocinétique et biodistribution du médicament. Thérapie génique anti-sens (ed. J.-M. Lhoste & C. Hélène), Editions INSERM, Paris (in French) [Text in full]

Hg13. A. Cornish-Bowden (1999) Metabolic control analysis in biotechnology and medicine, Nature Biotechnol. 17, 641–643 [ Download PDF ]