Sunday 11th April
1. Opening session
Chaired by Athel Cornish-Bowden(Marseilles)
- 9:00–9:15
- Athel Cornish-Bowden (Marseilles): Opening remarks and general information about the workshop
- 9:15–10:05
- James E. Bailey (Zürich): Life is complicated
2. Biotechnology I
Chaired by Jan-Hendrik Hofmeyr (Stellenbosch)
- 10:15–10:40
- James C. Liao (Los Angeles): Regulation and Redirection of Metabolism: toward prediction of metabolic fluxes
- 10:45–11:10
- Stefan Schuster (Berlin): Recent developments in metabolic pathway analysis and their potential implications for biotechnology and medicine
- 11:15–11:35
- Break
- 11:35–12:00
- Stephen Oliver (Manchester): Systematic functional analysis of the yeast genome
- 12:05–12:25
- Jacky L. Snoep (Amsterdam): Homeostatic control: how to turn it into a biotechnological advantage
- 12:25–12:50
- General discussion
- 1:00–2:30
- Lunch
3. Posters
- 3:15–4:15
- Viewing of posters (to be in place before 2:00)
- 4:15–4:35
- Break
4. Cancer
Chaired by David Fell (Oxford)
- 4:35–5:00
- Marta Cascante (Barcelona): Application of metabolic control analysis to the design of a new strategy for cancer therapy
- 5:05–5:30
- Peter Duesberg (Berkeley): Is aneuploidy the simple solution for cancer and genetic instability?
- 5:35–6:00
- David Rasnick (Berkeley): Metabolic control analysis shows how aneuploidy causes cancer
- 6:05–6:45
- General discussion, introduced by Boris Goldstein (Pushchino)
- 7:00–8:30
- Dinner
5. Biotechnology II
Chaired and introduced by Douglas B. Kell (Aberystwyth)
- 9:00–9:45 pm
- Douglas B. Kell (Aberystwyth): Snapshots of systems — Metabolic control analysis and biotechnology
- 9:45–11:00
- General discussion of the position paper by Douglas Kell and Pedro Mendes
|
Monday 12th April
6. Cell architecture I
Chaired by Paul Srere (Dallas)
- 9:00–9:10
- Judit Ovádi (Budapest): Introduction to the session on cell architecture
- 9:10–9:40
- Judit Ovádi (Budapest): Medical implications of cytoarchitectural analysis
- 9:45–10:15
- Kevin M. Brindle (Cambridge): Probing the cell interior with NMR spectroscopy
- 10:20–10:40
- Break
- 10:40–11:10
- Murray P. Deutscher (Miami): Supramolecular organization and substrate channelling in the mammalian protein synthesizing system
- 11:15–11.45
- Joan J. Guinovart (Barcelona): Translocation of mammalian glycogen synthases
- 11:50–12:45
- General discussion, introduced by Valdur Saks (Tallinn)
- 1:00–2:30
- Lunch
7. Poster discussion
Chaired and introduced by Christoph Giersch (Darmstadt)
- 3:00–3:15
- Christoph Giersch (Darmstadt): Theory and practice of determining control coefficients or Exploring the sea by swimming in the pool
- 3:15–4:00
- Discussion of posters displayed in Session 3
- 4:10–4:30
- Break
8. Cell architecture II
Chaired by Judit Ovádi (Budapest)
- 4:30–4:55
- Costantino Salerno (Rome): Metabolic distress associated with impaired control by alternate substrates: two examples taken from purine metabolism
- 5:00–5:25
- David Sullivan (Syracuse): Requirement for co-localization of glycolytic enzymes for flight muscle function in Drosophila
- 5:30–5:55
- Natalie S. Cohen (Los Angeles): Metabolite channelling and protein/protein interactions in the pathway of urea synthesis
- 6:05–6:45
- General discussion, introduced by Ferenc Orosz (Budapest)
- 7:00–8:30
- Dinner
9. Evolution of metabolism
Chaired and introduced by Enrique Meléndez-Hevia (La Laguna)
- 8:45–9:15 pm
- Enrique Meléndez-Hevia (La Laguna): Glycogen biosynthesis: a case for a general theory of metabolic regulation
- 9:15–10:30
- General discussion of issues relating to the evolution of metabolism
|
Tuesday 13th April
10. Energy metabolism
Chaired by Louis Hue (Brussels)
- 9:00–9:25
- Martin Brand (Cambridge): Regulation of energy metabolism in hepatocytes
- 9:30–9:55
- Loranne Agius (Newcastle): The control coefficient of glucokinase (hexokinase IV/D) in hepatocytes: a predictor of metabolic defects in MODY
- 10:00–10:20
- Break
- 10:20–10:45
- Jean-Pierre Mazat (Bordeaux): Threshold effect in oxidative phosphorylation and metabolic control analysis: tissue specificity, energy supply and energy demand
- 10:50–11:15
- Bernard Korzeniewski (Kraków): Regulation of ATP supply in muscle and its implications for the genesis of myopathies
- 11:30–12:30
- General discussion, introduced by Vida Mildaziene (Kaunas)
- 12:30–1:00
- Lunch
AFTERNOON: Visit to Budapest: details to be announced
- 7:30–9:00
- Dinner
11. Metabolic cascades
Chaired and introduced by María Luz Cárdenas (Marseilles)
- 9:15–9:45 pm
- María Luz Cárdenas (Marseilles): Coordination and homeostasis in the response to multiple signals. Role of metabolic cascades
- 9:45–10:30
- General discussion of the role of interconvertible enzymes in metabolism
|
Wednesday 14th April
12. Metabolic aspects of disease
Chaired by Reinhart Heinrich (Berlin)
- 9:00–9:25
- Athel Cornish-Bowden (Marseilles): Metabolic simulation and control analysis for combatting parasites
- 9:30–9:55
- Barbara M. Bakker (Delft): Differential metabolic control analysis to improve the selectivity of drugs against parasitic diseases
- 10:00–10:20
- Break
- 10:20–10:45
- Patti A. Quant (Ely): Towards understanding control of neonatal energy metabolism in clinical infants
- 10:50–11:15
- Victoria Guixé (Santiago): Physiological consequences of a non-regulated mutant phosphofructokinase from E. coli
- 11:20–12:30
- General discussion, introduced by Francisco Montero (Madrid)
- 1:00–2:30
- Lunch
13. Metabolic theory
Chaired by Eörs Szathmáry (Budapest)
- 3:00–3:25
- Luis Acerenza (Montevideo): Metabolic Control Design: implications and applications
- 3:30–3:55
- Reinhart Heinrich (Berlin): Predicting the structural design of metabolic pathways: an evolutionary approach
- 4:00–4:20
- Break
- 4:20–4:45
- Philip W. Kuchel (Sydney): Combined NMR experimental and computer-simulation study of 2,3-BPG metabolism in human erythrocytes
- 4:50–5:15
- Pedro Mendes (Santa Fe): Computational approaches to the study of biochemical pathways and metabolic control
- 5:20–6:30
- General discussion, introduced by Herbert Sauro (Edinburgh)
- 7:00–8:30
- Dinner
14. Large systems
Chaired and introduced by Toni Kazic (St Louis)
- 9:00–9:25 pm
- Toni Kazic (St Louis): Steps towards the analysis of large biochemical systems
- 9:30–10:30
- General discussion of large systems
|
Thursday 15th April
15. Metabolic regulation I
Chaired by Hans V. Westerhoff (Amsterdam)
- 9:00–9:25
- David A. Fell (Oxford): Exercising control when control is distributed
- 9:30–9:55
- Simon Thomas (Uxbridge): Multisite modulation in the control of glycolysis: balance of supply and demand?
- 10:00–10:20
- Break
- 10:20–11:05
- Jan-Hendrik S. Hofmeyr (Stellenbosch): Putting the cart before the horse: designing a metabolic system in order to understand it
- 11:10–11:35
- Stefan Szedlacsek (Bucharest): Time-dependent or steady-state control of metabolic systems?
- 11:40–12:40
- General discussion, introduced by Edda Klipp (Berlin)
- 1:00–2:30
- Lunch
16. Metabolic regulation II
Chaired by Philip Kuchel (Sydney)
- 3:00–3:25
- Johann M. Rohwer (Stellenbosch): An integrated approach to the analysis of the control and regulation of cellular systems
- 3:30–4:10
- Hans V. Westerhoff (Amsterdam): Metabolic control from the back-benches
- 4:15–4:45
- General discussion, introduced by Thierry Letellier (Bordeaux)
- 4:45–5:05
- Break
17. Future prospects for control analysis
Chaired by Athel Cornish-Bowden (Marseilles)
- 5:05–5:50
- Louis Hue (Brussels): Regulation versus control
- 5:55–6:40
- Paul A. Srere (Dallas): Metabolic control and metabolons in the millennium
- 6:45–7:00
- Athel Cornish-Bowden (Marseilles): Closing remarks
- 8:00–10:00
- Dinner
|
![[Made with a Macintosh]](images/macmade.gif){kind=small}
![[Best Viewed With Any Browser]](images/anybrows.gif){kind=small}
![[Lynx-friendly]](images/lynxok.gif){kind=small}
