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Publications récentes

par Brigitte Gontero, Laure Azzopardi - publié le , mis à jour le


- E Jensen, K Yangüez, F Carrière, Brigitte Gontero. Storage Compound Accumulation in Diatoms as Response to Elevated CO2 Concentration. Biology, MDPI, 2020, doi:10.3390/biology9010005. hal-02431926


- J Wattanakul, M Sahaka, Sawsan Amara, Syamila Mansor, B Gontero, F Carrière and David Gray. " In vitro digestion of galactolipids from chloroplast-rich fraction (CRF) of postharvest, pea vine field residue (haulm) and spinach leaves"
Food Funct., (2019), 10, 7806. DOI : 10.1039/c9fo01867k hal-02431885

- L Avilan, C Puppo, A Villain, E Bouveret, B Menand ,B Field & B. Gontero "RSH enzyme diversity for (p)ppGpp metabolism in Phaeodactylum tricornutum and other diatoms"
Scientific Reports (2019) 9:17682 |

- H.S. Jiang, Y. Zhang, Z.W. Lu, R. Lebrun, B. Gontero, W. Li
“Interaction between Silver Nanoparticles and Two Dehydrogenases : Role of Thiol Groups”
Small (2019)
doi:10.1002/smll.201900860 [Epub ahead of print] hal-02176577

- E.L. Jensen, R. Clement, A. Kosta, S.C. Maberly, B. Gontero
“A new widespread subclass of carbonic anhydrase in marine phytoplankton”
The ISME journal, International Society for Microbial Ecology (2019)
doi:10.1038/s41396-019-0426-8 [Epub ahead of print] hal-02176562

-  L. Prioretti, F. Carriere, B. Field, L. Avilan, M.H. Montane, B. Menand, B. Gontero
“Targeting TOR signaling for enhanced lipid productivity in algae”
Biochimie (2019)
doi:10.1016/j.biochi.2019.06.016 . [Epub ahead of print] Review. hal-02176524

- Salhi, A., Amara, S., Mansuelle, P., Puppo, R., Lebrun, R., Gontero, B., Aloulou, A., and Carriere, F.
“Characterization of all the lipolytic activities in pancreatin and comparison with porcine and human pancreatic juices”.
Biochimie (Juillet 2019)

- Launay, H., Receveur-Bréchot, V., Carrière, F., and Gontero, B.
“Orchestration of algal metabolism by protein disorder”
Archives of Biochemistry and Biophysics (Sept. 2019) 672, 108070.
free download until October 1, 2019 at []

Krayem Najeh, Parsiegla Goetz, Gaussier Hélène, Louati Hanen, Jallouli Raida, Mansuelle Pascal, Carrière Frédéric, Gargouri Youssef ;
"Functional characterization and FTIR-based 3D modeling of full length and truncated forms of Scorpio maurus venom phospholipase A2"
BBA - General Subjects (May 2018) 1862 : 5, 1247–1261

Zhang Y., Launay H., Schramm A., Lebrun R., Gontero B.,
“Exploring intrinsically disordered proteins in Chlamydomonas reinhardtii.”
Scientific Reports , (1er MAI 2018), 8-6805,

Launay H., Barré P., Puppo C., Zhang Y., Maneville S., Gontero B., Receveur-Bréchot V.
“Cryptic disorder out of disorder : Encounter between conditionally disordered CP12 and Glyceraldehyde-3-phosphate dehydrogenase”.
Journal of Molecular Biology , (13 AVRIL 2018), 430, 8,1218–1234. DOI:10.1016/j.jmb.2018.02.020 hal-01794097

Inès Belhaj, Sawsan Amara, Goetz Parsiegla, Priscila Sutto-Ortiz, Moulay Sahaka, Hafedh Belghith, Audric Rousset, Dominique Lafont and Frédéric Carrière.
"Galactolipase activity of Talaromyces thermophilus lipase on galactolipid micelles, monomolecular films and UV-absorbing surface-coated substrate"
BBA Mol Cell Biol Lipids (2018) 1863 (9):1006-1015. doi10.1016/j.bbalip.2018.05.016

Mileo E, Ilbert M, Barducci A, Bordes P, Castanie-Cornet MP, Garnier C, Genevaux P, Gillet R, Goloubinoff P, Ochsenbein F, Richarme G, Iobbi-Nivol C, Giudici-Orticoni MT, Gontero B, Genest O
“Emerging fields in chaperone proteins : A French workshop”.
Biochimie 151 (2018) : 159-165.
hal-01863220 hal-01875607v1

Huang WM, Shao H, Zhou SN, Zhou Q, Fu WL, Zhang T, Jiang HS, Li W, Gontero B, Maberly SC (2018) pp1 - 14
“Different CO2 acclimation strategies in juvenile and mature leaves of Ottelia alismoides”.
Photosynth Res

Y. Zhang, H. Launay, F. Liu, R. Lebrun, B. Gontero
“Interaction between adenylate kinase 3 and glyceraldehyde-3-phosphate dehydrogenase from Chlamydomonas reinhardtii
The FEBS Journal 285 (2018) 2495–2503
doi:10.1111/febs.14494 hal-01833991

- Luisana Avilan, Carine Puppo, Adrien Villain, Emmanuelle Bouveret, Benoit Menand, Benjamin Field, Brigitte Gontero.
“Golden magic : RSH enzymes for (p)ppGpp metabolism in the diatom Phaeodactylum tricornutum”. bioRxiv peer preprint Nov. 2018

L. Humbert, D. Rainteau, N. Tuvignon, C. Wolf, P. Seksik, R. Laugier, F. Carrière
"Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients"
Journal of Lipid Research, (2018), 59 (11), pp.2202-2213

Maberly, S. C., and Gontero, B.
"Trade-offs and synergies in the structural and functional characteristics of leaves photosynthesizing in aquatic environments",
In "The Leaf : A Platform for Performing Photosynthesis". Advances in Photosynthesis and Respiration (W. W. Adams III, I. T., Ed.) (2018), pp 307-343, Springer International Publishing. []

Maberly SC & Gontero B
“Ecological imperatives for aquatic carbon dioxide-concentrating mechanisms”.
J Exp Bot ,(22 June 2017) 68 (14) pp 3797–3814

Jensen E, Clement R, Maberly SC & Gontero B
“Regulation of the Calvin-Benson-Bassham cycle in the enigmatic diatoms : biochemical and evolutionary variations on an original theme”.
Phil Trans Roy Soc 372 (1728) (05 Sept 2017) ;

_Lavoie I, Hamilton PB, Morin S, Kim Tiam S, Kahlert M, Gonçalves S, Falasco E, Fortin C, Gontero B, Heudre D, Kojadinovic M, Manoylov K , Pandey L. K., Taylor J. C..
"Diatom teratologies as biomarkers of contamination : Are all deformities ecologically meaningful ?"
Ecological Indicators (Nov. 2017) 82, pp 539-550,

_Prioretti L, Avilan L, Carriere F, Montané M, Field B, Gregori G, Menand B, Gontero B. .
"The inhibition of TOR in the model diatom Phaeodactylum tricornutum promotes a get-fat growth regime".
Algal Research (2017) 26 : 265-274.
hal-01620276- hal-01696878

Shao H, Gontero B, Maberly SC, Jiang HS, Cao Y, Li W, Huang WM. (2017) “Responses of Ottelia alismoides, an aquatic plant with three CCMs, to variable CO2 and light”.
J. Exp. Bot. 68(14):3985-3995. doi:10.1093/jxb/erx064 hal-01535902

Clement R., Lignon S., Mansuelle P., Jensen E., Pophillat M., Lebrun R., Denis Y., Puppo C., Maberly S. C. & Gontero B (2017) Responses of the marine diatom
Thalassiosira pseudonana to changes in CO2 concentration : a proteomic approach. Sci. Reports 7:42333 doi:10.1038/srep42333

Clement R., Jensen E., Prioretti L, Maberly S.C & Gontero B (2017) Diversity of CO2 concentrating mechanisms and responses to CO2 concentration in marine and freshwater diatoms.
J. Exp. Bot. 68(14):3925-3935. DOI:10.1093/jxb/erx035 hal-01514716

Jiang HS, Yin L, Ren NN, Xian L, Zhao S, Li W, Gontero B. (2017).
The effect of chronic silver nanoparticles on aquatic system in microcosms.
Environ Pollut. . pii : S0269-7491(16)31066-1. doi:10.1016/j.envpol.2017.01.036. hal-01439047

Jiang HS, Yin LY, Ren NN, Zhao ST, Li Z, Zhi Y, Shao H, Li W, Gontero B. “Silver nanoparticles induced reactive oxygen species via photosynthetic energy transport imbalance in an aquatic plant.”
Nanotoxicology  :(19 January 2017), pp.1 - 42. doi:10.1080/17435390.2017.1278802 hal-01438853

Adrien Villain, Mila Kojadinovic, Carine Puppo, Laura Prioretti, Pierre Hubert, Yizhi Zhang, Gerald Gregori, Alain Roulet, Jean-Michel Claverie, Brigitte Gontero, and Guillaume Blanc.(16 Febr. 2017) - 2 (1) pp-97-98
“Complete Mitochondrial Genome Sequence of the freshwater diatom Asterionella formosa”.
Mitochondrial DNA Part B . doi:10.1080/23802359.2017.1285210 hal-01440840


- Prioretti L, Lebrun R, Gontero B, Giordano M (2016). Redox regulation of ATP sulfurylase in microalgae. Biochem Biophys Res Commun. 478(4):1555-62. doi : 10.1016/j.bbrc.2016.08.151. Epub 2016 Sep 7.

- Thieulin-Pardo G, Schramm A, Lignon S, Lebrun R, Kojadinovic M, Gontero B (2016). The intriguing CP12-like tail of adenylate kinase 3 from Chlamydomonas reinhardtii. FEBS J. 283(18):3389-407. doi : 10.1111/febs.13814. Epub 2016 Aug 5.

- Launay H, Barré P, Puppo C, Manneville S, Gontero B, Receveur-Bréchot V (2016). Absence of residual structure in the intrinsically disordered regulatory protein CP12 in its reduced state. Biochem Biophys Res Commun. 477(1):20-6. doi : 10.1016/j.bbrc.2016.06.014.

- Clement R, Dimnet L, Maberly SC, & Gontero B (2016) The nature of the CO2 concentrating mechanisms in a marine diatom, Thalassiosira pseudonana. New Phytol 209(4):1417-1427.

- Vogwill T, Kojadinovic M, MacLean RC (2016) Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas. Proc Biol Sci. May 11 ;283(1830). pii : 20160151. doi : 10.1098/rspb.2016.0151.


- Mihoub, M., Abdallah, J., Gontero, B., Dairou, J., and Richarme, G. (2015) The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal, Biochem Biophys Res Commun. 463(4), 1305-1310.

- Thieulin-Pardo, G., Avilan, L., Kojadinovic, M., and Gontero, B. (2015) Fairy "tails" : flexibility and function of intrinsically disordered extensions in the photosynthetic world, Front Mol Biosci 2, 23.

- Goncalves, A., Gontero, B., Nowicki, M., Margier, M., Masset, G., Amiot, M.-J., and Reboul, E. (2015) Micellar Lipid Composition affects Micelle Interaction with Class B Scavenger Receptors extracellular loops, Journal of Lipid Research 56, 1123-1133.

- Gifford, D. R., Toll-Riera, M., Kojadinovic, M., MacLean, R. C. (2015) Here’s to the Losers : Evolvable Residents Accelerate the Evolution of High-Fitness Invaders, Am Nat 186, 41-49.

- Torres-Barcelo C, Kojadinovic M, Moxon R, & MacLean RC (2015) The SOS response increases bacterial fitness, but not evolvability, under a sublethal dose of antibiotic. Proc Biol Sci 282(1816):20150885

- Thieulin-Pardo, G., Remy, T., Lignon, S., Lebrun, R., and Gontero, B. (2015) Phosphoribulokinase from Chlamydomonas reinhardtii : a Benson-Calvin cycle enzyme enslaved to its cysteine residues, Mol Biosyst 11, 1134-1145.

- Moparthi, S. B., Thieulin-Pardo, G., de Torres, J., Ghenuche, P., Gontero, B., and Wenger, J. (2015) FRET analysis of CP12 structural interplay by GAPDH and PRK, Biochem Biophys Res Commun 458, 488-493.

- Maberly, S. C., Berthelot, S. A., Stott, A. W. and Gontero, B. (2015) Adaptation by macrophytes to inorganic carbon down a river with naturally variable concentrations of CO2 Journal of Plant Physiol 172, 120-127.


- Gontero, B., and Salvucci, M. (2014) Regulation of photosynthetic carbon metabolism in aquatic and terrestrial organisms by Rubisco activase, redox-modulation and CP12, Aquatic Botany Review, 118, 14-23.

- Moparthi, S. B., Thieulin-Pardo, G., Mansuelle, P., Rigneault, H., Gontero, B., and Wenger, J. (2014) Conformational modulation and hydrodynamic radii of CP12 protein and its complexes probed by Fluorescence Correlation Spectroscopy, FEBS J 281, 3206-3217.

- Mekhalfi, M., Puppo, C., Avilan, L., Lebrun, R., Mansuelle, P., Maberly, S. C., and Gontero, B. (2014) Glyceraldehyde-3-phosphate dehydrogenase is regulated by ferredoxin-NADP reductase in the diatom Asterionella formosa, New Phytol 203, 414-423.

- Vogwill, T., Kojadinovic, M., Furió, V., MacLean, R. C. (2014) Testing the role of genetic background in parallel evolution using the comparative experimental evolution of antibiotic resistance. (2014) Mol Biol Evol 31, 3314-3323.

- Mekhalfi, M., Amara, S., Robert, S., Carriere, F., and Gontero, B. (2014) Effect of environmental conditions on various enzyme activities and triacylglycerol contents in cultures of the freshwater diatom, Asterionella formosa (Bacillariophyceae), Biochimie 101, 21-30.

- Marri L, Thieulin-Pardo G, Lebrun R, Puppo R, Zaffagnini M, Trost P, Gontero B, Sparla F. (2014) CP12-mediated protection of Calvin-Benson cycle enzymes from oxidative stress. Biochimie 97 : 228-237.


- Zhang Y, Yin L, Jiang HS, Li W, Gontero B, Maberly SC. Biochemical and biophysical CO2 concentrating mechanisms in two species of freshwater macrophyte within the genus Ottelia (Hydrocharitaceae). Photosynthesis Research 2013 Nov 8. [Epub ahead of print] PMID:24203583

- Mileo E, Etienne E, Martinho M, Lebrun R, Roubaud V, Tordo P, Gontero B, Guigliarelli B, Marque SR, Belle V. Enlarging the Panoply of Site-Directed Spin Labeling Electron Paramagnetic Resonance (SDSL-EPR) : Sensitive and Selective Spin-Labeling of Tyrosine Using an Isoindoline-Based Nitroxide. Bioconjug Chem. 2013 24(6):1110-7. doi : 10.1021/bc4000542. Epub 2013 May 22.

- Kaaki W, Woudstra M, Gontero B & Halgand F (2013) Exploration of CP12 conformational changes and of quaternary structural properties using electrospray ionisation traveling wave ion mobility mass spectrometry. Rapid Commun Mass Spectrum 27, 1-8, doi : 10.1002/rcm.6442.


- Gontero B. & Maberly, S.C (2012) An intrinsically disordered protein, CP12 : jack of all trades and master of the Calvin cycle. Biochem. Soc. Trans. 40 (5), 995-999. doi:10.1042/BST20120097.

- L. Avilan , C. Puppo , J. Erales , M. Woudstra , R. Lebrun & B. Gontero (2012) CP12 residues involved in the formation and regulation of the Glyceraldehyde-3-phosphate dehydrogenase CP12-Phosphoribulokinase complex in Chlamydomonas reinhardtii. Mol. BioSyst. 8 (11), 2994 - 3002, DOI : 10.1039/C2MB25244A

- Avilan L, Maberly SC, Mekhalfi M, Plateau J, Puppo C & Gontero B (2012) Regulation of glyceraldehyde-3-phosphate dehydrogenase in the eustigmatophyte Pseudocharaciopsis ovalis is intermediate between a chlorophyte and a diatom. European Journal of Phycology 47, 207-215, doi : 10.1080/09670262.2012.687459.

- Mekhalfi M, Avilan L, Lebrun R, Botebol H & Gontero B (2012) Consequences of the presence of 24-epibrassinolide, on cultures of a diatom, Asterionella formosa. Biochimie 94, 1213-1220, doi : 10.1016/j.biochi.2012.02.011.

- Zaffagnini M, Bedhomme M, Groni H, Marchand CH, Puppo C, Gontero B, Cassier-Chauvat C, Decottignies P, Lemaire SD. (2012) Glutathionylation in the photosynthetic model organism Chlamydomonas reinhardtii : a proteomic survey. Mol. Cell. Proteomics 11, M111 014142, doi : M111.014142 [pii]


- Gontero B & Avilan L. (2011) Creating order out of disorder : structural imprint of GAPDH on CP12.Structure 19, 1728-1729, doi : S0969-2126(11)00417-5 [pii]

- Lorenzi M, Puppo C, Lebrun R, Lignon S, Roubaud V, Martinho M, Mileo E, Tordo P, Marque SR, Gontero B, et al. (2011) Tyrosine-Targeted Spin Labeling and EPR Spectroscopy : An Alternative Strategy for Studying Structural Transitions in Proteins. Angew Chem Int Ed Engl Angew Chem 50(39):9108-11. doi : 10.1002/anie.201102539

- Erales J, Mekhalfi M, Woudstra M & Gontero B (2011) Molecular mechanism of NADPH-glyceraldehyde-3-phosphate dehydrogenase regulation through the C-terminus of CP12 in Chlamydomonas reinhardtii. Biochemistry 50, 2881-2888, doi : 10.1021/bi1020259.


- Groben R, Kaloudas D, Raines CA, Offmann B, Maberly SC & Gontero B (2010) Comparative sequence analysis of CP12, a small protein involved in the formation of a Calvin cycle complex in photosynthetic organisms. Photosynth Res. 103, 183-194.

- Maberly SC, Courcelle C, Groben R & Gontero B (2010) Phylogenetically-based variation in the regulation of the Calvin cycle enzymes, phosphoribulokinase and glyceraldehyde-3-phosphate dehydrogenase, in algae. J. Exp. Bot. 61 (3), 735-745.


- Erales J, Lorenzi M, Lebrun R, Fournel A, Etienne E, Courcelle C, Guigliarelli B, Gontero B & Belle V (2009) A new function of GAPDH from Chlamydomonas reinhardtii : a thiol-disulfide exchange reaction with CP12, Biochemistry. 48, 6034-40.

- Erales J, Lignon S & Gontero B (2009) CP12 from Chlamydomonas reinhardtii, a Permanent Specific "Chaperone-like" Protein of Glyceraldehyde-3-phosphate Dehydrogenase, J Biol Chem. 284, 12735-44.

- Erales J, Gontero B, Whitelegge J & Halgand F (2009) Mapping of a copper-binding site on the small CP12 chloroplastic protein of Chlamydomonas reinhardtii using top-down mass spectrometry and site-directed mutagenesis, Biochem J. 419, 75-82.

- Atteia A, Adrait A, Brugiére S, Tardif M, van Lis R, Deusch O, Dagan T, Kuhn L, Gontero B, Martin W, Garin J, Joyard J & Rolland N (2009) A proteomic survey of Chlamydomonas reinhardtii mitochondria sheds new light on the metabolic plasticity of the organelle and on the nature of the alpha-proteobacterial mitochondrial ancestor, Mol Biol Evol. 26, 1533-1548.

- Rolland N, Atteia A, Decottignies P, Garin J, Hippler M, Kreimer G, Lemaire SD, Mittag M, Wagner V (2009) Curr Opin Microbiol. 12, 285-291.


- Erales J, Gontero B & Maberly SC (2008) Specificity and function of glyceraldehyde-3-phosphate dehydrogenase in a freshwater diatom, Asterionella formosa (BACILLARIOPHYCEAE), Journal of Phycology. 44, 1455-1464.

- Erales J, Avilan L, Lebreton S & Gontero B (2008) Exploring CP12 binding proteins revealed aldolase as a new partner for the phosphoribulokinase/glyceraldehyde 3-phosphate dehydrogenase/CP12 complex - purification and kinetic characterization of this enzyme from Chlamydomonas reinhardtii, Febs J. 275, 1248-1259.


- Boggetto N, Gontero B & Maberly SC (2007) Regulation of phosphoribulokinase and glyceraldehyde 3-phosphate dehydrogenase in a freshwater diatom, Asterionella formosa, Journal of Phycology. 43, 1227-1235.

- van Lis R, Mendoza-Hernández G, Groth G, Atteia A (2007) New insights into the unique structure of the F0F1-ATP synthase from the chlamydomonad algae Polytomella sp. and Chlamydomonas reinhardtii. Plant Physiol 144,1190-1199.


- Offmann B, Gardebien F, Thangudu RR & Gontero B (2006) Construction of a 3D model of CP12, a protein linker, Journal of Molecular Graphics & Modelling|Journal of Molecular Graphics & Modelling. 25, 186-95.

- Lebreton S, Andreescu S, Graciet E & Gontero B (2006) Mapping of the interaction site of CP12 with glyceraldehyde-3-phosphate dehydrogenase from Chlamydomonas reinhardtii - Functional consequences for glyceraldehyde-3-phosphate dehydrogenase, Febs Journal. 273, 3358-3369.

- Gontero B, Avilan L & Lebreton S (2006) Control of carbon fixation in chloroplasts, Annual Plant Reviews. 22, 187-218.

- Gardebien F, Thangudu RR, Gontero B & Offmann B (2006) Construction of a 3D model of CP12, a protein linker, Journal of Molecular Graphics & Modelling. 25, 186-195.

- Atteia A, van Lis R, Gelius-Dietrich G, Adrait A, Garin J, Joyard J, Rolland N, Martin W (2006) Pyruvate formate-lyase and a novel route of eukaryotic ATP-synthesis in Chlamydomonas mitochondria. J Biol Chem. 281, 9909-9918.